1279691-23-4

Basic information

• Product Name: 3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydropyrazole-1-carbothioamide
• Synonyms: 3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydropyrazole-1-carbothioamide
• CAS NO: 1279691-23-4
• Molecular Weight: 394.722
• Mol File: 1279691-23-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydropyrazole-1-carbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydropyrazole-1-carbothioamide(1279691-23-4)
• EPA Substance Registry System: 3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydropyrazole-1-carbothioamide(1279691-23-4)

Safety Data

• Hazardous Substances Data: 1279691-23-4(Hazardous Substances Data)

Upstream product

• 296271-45-9 1-(4-bromophenyl)-3-(4-chlorophenyl)propan-1-one 
• 79-19-6 thiosemicarbazide 
• 99-90-1 para-bromoacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 6332-22-5 1-(4-bromophenyl)-3-(4-chlorophenyl)prop-2-en-1-one 

Downstream Products

• 1234016-36-4 C₂₄H₁₇BrClN₃S 
• 1382922-81-7 5-benzylidene-2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one 
• 1382922-83-9 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(4-chlorobenzylidene)-1,3-thiazol-4(5H)-one 
• 1382922-85-1 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(2-methoxybenzylidene)-1,3-thiazol-4(5H)-one 
• 1382922-87-3 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one 
• 1382922-89-5 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one 
• 1382922-91-9 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(3-nitrobenzylidene)-1,3-thiazol-4(5H)-one 
• 1279691-27-8 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydropyrazol-1-yl]-4-oxo-4,5-dihydrothiazole 
• 1279691-25-6 2-[3-(4-bromophenyl)-5-(4-chlorophenyl)-4,5-dihydropyrazol-1-yl]-4-(4'-bromophenyl)thiazole 

Relevant articles and documents

Synthesis, characterization, and biological evaluation of certain 1,3-thiazolone derivatives bearing pyrazoline moiety as potential anti-breast cancer agents

A series of 5-arylidene-2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-1,3- thiazol-4(5H)-ones were synthesized and screened for their in vitro antitumor activity against human breast adenocarcinoma cell line (MCF-7). Five of the test compounds exhibited good antitumor activity superior to the reference drug, doxorubicin, with IC50 range 1.4-2.3 μM. Among the test compounds, 2-[3,5-bis(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(2- methoxybenzylidene)-1,3-thiazol-4(5H)-one (3i) was found to show the most potent anticancer activity.

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents

Fourty-two thiazolyl-pyrazoline derivatives were synthesized to screen for their EGFR kinase inhibitory activity. Compound 4-(4-chlorophenyl)-2-(3-(3,4- dimethylphenyl)-5-p-tolyl-4,5-dihydro-1H-pyrazol-1-yl)thiazole (11) displayed the most potent EGFR TK inhibitory activity with IC50 of 0.06 μM, which was comparable to the positive control. Molecular docking results indicated that compound 11 was nicely bound to the EGFR kinase. Compound 11 also showed significant antiproliferative activity against MCF-7 with IC 50 of 0.07 μM, which would be a potential anticancer agent.