1382936-45-9Relevant academic research and scientific papers
Identification of benzoxazole analogs as novel, S1P3 sparing S1P1 agonists
Deng, Guanghui,Meng, Qinghua,Liu, Qian,Xu, Xuesong,Xu, Qiongfeng,Ren, Feng,Guo, Taylor B.,Lu, Hongtao,Xiang, Jia-Ning,Elliott, John D.,Lin, Xichen
, p. 3973 - 3977 (2012/07/03)
A novel series of benzoxazole-derived S1P1 agonists were designed based on scaffold hopping molecular design strategy combined with computational approaches. Extensive SAR studies led to the discovery of compound 17d as a selective S1P1 agonist (over S1P3) with high CNS penetration and favorable DMPK properties. 17d also demonstrated in vivo pharmacological efficacy to reduce blood lymphocyte in mice after oral administration.
