25391-59-7

Basic information

• Product Name: 2-Hydroxy-5-iodo-3-nitropyridine
• Synonyms: 2-Hydroxy-5-iodo-3-nitropyridine;5-IODO-3-NITROPYRIDIN-2-OL
• CAS NO: 25391-59-7
• Molecular Formula: C5H3IN2O3
• Molecular Weight: 266
• Mol File: 25391-59-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 252-256°C
• Boiling Point: 385.4°C at 760 mmHg
• Flash Point: 186.9°C
• Appearance: /
• Density: 2.312g/cm³
• Vapor Pressure: 1.72E-06mmHg at 25°C
• Refractive Index: 1.725
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 6.50±0.10(Predicted)
• CAS DataBase Reference: 2-Hydroxy-5-iodo-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-5-iodo-3-nitropyridine(25391-59-7)
• EPA Substance Registry System: 2-Hydroxy-5-iodo-3-nitropyridine(25391-59-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 25391-59-7(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-5-iodo-3-nitropyridine is a chemical compound with the molecular formula C5H3IN2O3. It consists of a pyridine ring with hydroxy, iodo, and nitro functional groups attached to it. 2-Hydroxy-5-iodo-3-nitropyridine is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is also used in the production of dyes and pigments. 2-Hydroxy-5-iodo-3-nitropyridine may have potential applications in the field of material science due to its unique structural properties and reactivity. It is important for researchers and chemists to handle this compound with care, as it may pose certain health and safety risks.

InChI:InChI=1/C5H3IN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9)

Upstream product

• 6332-56-5 2-hydroxy-3-nitropyridine 
• 6332-56-5 3-nitropyridone 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 20511-12-0 2-amino-5-iodopyridine 

Downstream Products

• 426463-05-0 2-chloro-5-iodo-3-nitro-pyridine 
• 1382936-41-5 C₂₀H₂₁ClN₂O₄ 
• 1382936-42-6 C₁₆H₁₃ClN₂O₄ 
• 1382936-39-1 C₁₅H₁₄ClIN₂O₃ 
• 1382936-40-4 C₁₅H₁₂ClIN₂O₂ 
• 1382936-43-7 C₁₇H₁₅ClN₂O₄ 
• 1382936-50-6 C₂₂H₂₅ClN₂O₄ 
• 1382936-47-1 C₁₉H₁₉ClN₂O₄ 
• 1382936-48-2 C₂₀H₂₁ClN₂O₄ 
• 1382936-49-3 C₂₁H₂₃ClN₂O₄ 
• 1382936-51-7 C₂₃H₂₇ClN₂O₄ 
• 1382936-44-8 C₁₈H₁₇ClN₂O₄ 
• 1382936-45-9 C₁₉H₁₉ClN₂O₄ 
• 1382936-46-0 C₂₁H₂₃ClN₂O₄ 

Relevant articles and documents

5-Azidoepibatidine: An Exceptionally Potent Photoaffinity Ligand for Neuronal α4β2 and α7 Nicotinic Acetylcholine Receptors

Racemic 5-azidoepibatidine [(+/-)-1] was synthesized via 5-aminoepibatidine as a candidate photoaffinity ligand with exceptionally high affinity at the mammalian neuronal nicotinic receptors (Ki values of 0.027 nM for α4β2 and 9.7 nM for α7) and excellent photoreactivity.

ANTI-FIBROTIC PYRIDINONES

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Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin- 7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain

We report the synthesis and SAR of a series of novel azaindole CB 2 agonists. 6-Azaindole 18 showed activity in an acute pain model but was inactive in a chronic model. 18 is a Pgp substrate with low brain penetration. The template was redesign