1382976-53-5

Basic information

• Product Name: (R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid
• Synonyms: (R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid
• CAS NO: 1382976-53-5
• Molecular Weight: 527.912
• Mol File: 1382976-53-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid(1382976-53-5)
• EPA Substance Registry System: (R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid(1382976-53-5)

Safety Data

• Hazardous Substances Data: 1382976-53-5(Hazardous Substances Data)

Upstream product

• 352535-83-2 5-chloro-2-fluorophenylboronic acid 
• 842973-74-4 3-(2-fluorophenyl)isoxazole-5-carboxylic acid 

Relevant articles and documents

NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula X where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds