1383028-76-9

Upstream product

• 773837-37-9 sodium cyanide 
• 32454-16-3 2-(4-bromophenyl)-2-methyl-propionaldehyde 
• 506-87-6 ammonium carbonate 
• 101184-73-0 2-(4-bromophenyl)-2-methylpropanenitrile 

Downstream Products

• 1383029-27-3 (S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester 
• 1401603-51-7 C₁₂H₁₆BrNO₂ 
• 1383029-05-7 C₁₉H₂₀BrNO₃ 
• 1432502-56-1 C₂₈H₃₃NO₇ 
• 1383029-23-9 C₂₈H₃₅NO₆ 
• 1394050-37-3 C₂₇H₃₄N₂O₃ 
• 1432502-60-7 C₂₅H₂₉NO₄ 
• 1394050-39-5 C₂₅H₃₁NO₄ 
• 1383028-96-3 C₁₉H₂₀BrNO₃ 
• 1383028-90-7 C₂₀H₂₂BrNO₃ 
• 676627-65-9 C₁₁H₁₄BrNO₂ 

Relevant academic research and scientific papers

NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.