13831-02-2Relevant academic research and scientific papers
Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs)
Gorsuch, Stephen,Bavetsias, Vassilios,Rowlands, Martin G.,Aherne, G. Wynne,Workman, Paul,Jarman, Michael,McDonald, Edward
experimental part, p. 467 - 474 (2009/07/25)
High-throughput screening led to the identification of isothiazolones 1 and 2 as inhibitors of histone acetyltransferase (HAT) with IC50s of 3 μM and 5 μM, respectively. Analogues of these hit compounds with variations of the N-phenyl group, and with vari
A General Synthesis of N-Substituted Isothiazol-3(2H)-ones
Beeley, Nigel R. A.,Harwood, Laurence M.,Hedger, Paul C.
, p. 2245 - 2252 (2007/10/02)
A general route to the synthesis of N-substituted isothiazol-3(2H)-ones (4a-i) is described which proceeds via trichloroacetic acid-mediated ring closure of N-substituted (Z)-3-(benzylsulfinyl)propenamides (15a-i).
