1383114-86-0Relevant articles and documents
Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives
Secci, Daniela,Bizzarri, Bruna,Bolasco, Adriana,Carradori, Simone,D'Ascenzio, Melissa,Rivanera, Daniela,Mari, Emanuela,Polletta, Lucia,Zicari, Alessandra
, p. 246 - 253 (2012/08/28)
Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity.