1383117-23-4Relevant academic research and scientific papers
Total synthesis of ecteinascidin 743
Kawagishi, Fumiki,Toma, Tatsuya,Inui, Tomohiko,Yokoshima, Satoshi,Fukuyama, Tohru
, p. 13684 - 13687 (2013)
A straightforward synthesis of ecteinascidin 743 was accomplished from readily available l-glutamic acid as a single chiral source. Our novel synthesis features a concise and convergent approach for construction of the B-ring, consisting of a sequence involving a stereoselective Heck reaction between a diazonium salt and an enamide, oxidative cleavage of the resulting alkene, and intramolecular ortho substitution of the phenol by an aldehyde.
