138313-58-3

Upstream product

• 138313-57-2 2,2,2-Trichlorethanimidsaeure-O-(3-phenyl-2-butenyl)ester 
• 54976-37-3 3-phenylbut-2-en-1-ol 
• 1504-72-9 ethyl 3-phenylbut-2-enoate 
• 54976-38-4 (E)-3-phenylbut-2-en-1-ol 
• 273377-11-0 (E)-3-phenylbut-2-enyl 2,2,2-trichloroethanimidoate 

Downstream Products

• 86766-67-8 2-Phenyl-3-buten-2-ylamin 
• 138313-53-8 2-Phenyl-3-buten-2-ylisocyanid 
• 138313-54-9 N-(2-Phenyl-3-buten-2-yl)formamid 
• 13312-99-7 2-methyl-2-phenyl-3-butenenitrile 
• 2288-18-8 2-phenyl-1,3-butadiene 
• 256950-60-4 tert-butyl 1-methyl-1-phenylprop-2-enylcarbamate 

Relevant academic research and scientific papers

Rearrangement Reactions Leading to Optically Active α,α-Disubstituted Primary Allylamines

Synthetic routes to α,α-disubstituted allylamines have been examined. Racemic compounds were conveniently prepared by thermal Overman rearrangements of primary allylic alcohols with trisubstituted double bonds, but rearrangement of these substrates using

MITOTIC KINESIN INHIBITORS

The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions

Overman rearrangement of γ-aryl crotyl alcohols: Effects of aryl substituents

Various α,α'-methyl aryl allylic amines were synthesized from γ-aryl crotyl alcohols via thermal Overman rearrangement. Noteworthy is that the presence of the electron withdrawing groups at aryl group causes substantial increases in the reaction rates and

Ring closing metathesis of phenyl-substituted dienes

A series of phenyl-substituted heterodienes 2a-f and 6 was prepared and subjected to ring closing metathesis (RCM) to give differently phenyl- substituted dihydropyrroles and dihydrofuran.

New Syntheses of Isomerically Pure Allyl and Propargyl Cyanides by Isocyanide-Cyanide Rearrangement

A new route for the synthesis of isomerically pure allyl and propargyl cyanides has been developed.Allylic amines are synthesized from the corresponding alcohols by Mitsunobu or by Overman reaction.Formylation with formic acid derivatives provides N-substituted formamides, which are dehydrated to isocyanides. 1,2-Sigmatropic rearrangement by flash pyrolysis provides the isomerically pure allyl and propargyl cyanides. Key Words: Isocyanide-cyanide rearrangment / Cyanides, allyl- and propargyl-