138320-26-0

Basic information

• Product Name: Hexanoic acid, 2-(2-formylphenoxy)-, methyl ester
• CAS NO: 138320-26-0
• Molecular Formula: C14H18O4
• Molecular Weight: 250.295
• Mol File: 138320-26-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Hexanoic acid, 2-(2-formylphenoxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanoic acid, 2-(2-formylphenoxy)-, methyl ester(138320-26-0)
• EPA Substance Registry System: Hexanoic acid, 2-(2-formylphenoxy)-, methyl ester(138320-26-0)

Safety Data

• Hazardous Substances Data: 138320-26-0(Hazardous Substances Data)

Upstream product

• 5445-19-2 methyl 2-bromohexanoate 
• 90-02-8 salicylaldehyde 

Downstream Products

• 83790-87-8 2-n-butyl 3-(4-methoxy benzoyl)-benzofuran 
• 335153-23-6 methyl 2-(2-formyl-4-nitrophenoxy)hexanoate 
• 97025-19-9 2-(o-carboxyphenoxy)hexanoic acid 
• 158745-57-4 2-(o-carboxyphenoxy)hexylamide 
• 4265-27-4 2-n-butylbenzo[b]furan 
• 138320-27-1 2-(2-formyl-phenoxy)-hexanoic acid 
• 158745-56-3 2-(o-formylphenoxy)hexylamide 
• 1951-26-4 2-n-butyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)benzofuran 
• 52490-15-0 2-n-Butyl-3-(4-hydroxy-benzoyl)-benzofuran 
• 19774-82-4 amiodarone hydrochloride 

Relevant articles and documents

Preparation method of amiodarone hydrochloride intermittent

The invention belongs to the field of medicine synthesis, and relates to a preparation method of an amiodarone hydrochloride intermittent. The method is characterized by including the following stepsthat 1, under an alkaline condition, in the presence of a phase transfer catalyst, a compound 1 and a compound 2 are subjected to nucleophilic substitution reaction to obtain a compound 3; 2, under analkaline condition, the compound 3 is hydrolyzed to generate a compound 4; 3, the compound 4 is subjected to intramolecular aldol condensation, decarboxylation and dehydration to obtain a compound 5;4, a compound 6 and thionyl chloride are subjected to heating reaction to obtain a compound 7; 5, under the presence of lewis acid, the compound 5 and the compound 7 are subjected to friede-crafts acylation reaction to obtain a compound 8; 6, under the presence of lewis acid, the compound 8 is subjected to demethylation to generate a compound 9, namely the amiodarone hydrochloride intermittent 2-butyl-3-(4-hydroxybenzoyl)benzofuran. The preparation method of the amiodarone hydrochloride intermittent has the advantages of being short in reaction time, high in product purity and high in yield,and the amiodarone hydrochloride intermittent is suitable for large-scale industrial production.

Amiodarone hydrochloride preparation method

The invention belongs to the field of medicine, and especially relates to an amiodarone hydrochloride preparation method. The method takes 2-hydroxybenzaldehyde and 2-alkyl halohexoic acid ester as the raw materials to prepare 2-butylbenzofuran, 2-butylbenzofuran is taken as the raw material, and is subjected to the steps of friedel-crafts acylation, demethylation, iodination, etherification and salt forming to obtain the amiodarone hydrochloride. By employing the method, the raw materials have the advantages of low cost and easy acquisition, the process is simple, and 2-butylbenzofuran and amiodarone hydrochloride with high purity and high yield can be obtained, the cost is low, the waste water is little, and the method is suitable for industrial production.

Method of preparing a benzofuran or benzothiophene compound

The invention concerns a novel method for preparing a benzofuran or benzothiophene compound by cyclizing an aromatic compound bearing a side-chain comprising at least two carbon atoms, one of the carbon atoms being bound to the benzene cycle by an oxygen or sulphur atom, the other carbon atom is in carboxylic form and a formyl radical in ortho position relative to said chain. The inventive method is characterised in that it consists in cyclizing the latter in the presence of an efficient amount of a carbonate base in a medium comprising a carboxylic acid anhydride and optionally an organic solvent.