13833-89-1Relevant academic research and scientific papers
Preparation of Some Novel S-Nitroso Compounds as Potential Slow-release Agents of Nitric Oxide in vivo
Moynihan, Humphrey A.,Roberts, Stanley M.
, p. 797 - 806 (2007/10/02)
The optimum conditions for the preparation of N-acetyl-S-nitrosopenicillamine (SNAP) 3 were determined and applied to the synthesis of the corresponding N-formyl compound 7.The nitrosation of penicillamine dipeptides was investigated and bis-thionitroso compounds 13, 18, 26 and 27 were isolated.S,S'-Dinitroso dithiol 13 showed biological activity akin to that of glyceryl trinitrate in decreasing systemic arterial blood pressure in anaesthetized rats and rabbits.Concomitant inhibition of collagen- or ADP-induced platelet aggregation was observed.
Aqueous and Anhydrous Degradations of 6α-Formamidopenicillins
Cutmore, E. Alan,Guest, Angela W.,Hatto, Julia D. I.,Moores, Clive J.,Smale, Terence C.,et al.
, p. 847 - 853 (2007/10/02)
When an aqueous solution of the 6α-formamidopennicilin BRL 36650 (1) was set aside for 36 h, an essentially quantitative C(5)-C(6) cleavage resulted, yielding the α,α-bis(acylamino) acid (6) and N-formylpenicillamine (10).The unsubstituted phenyl compound
