138332-82-8

Basic information

• Product Name: (1S,2R,6S,7R)-4-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.0^2,6]decane-3,5-dione
• Synonyms: (1S,2R,6S,7R)-4-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.0^2,6]decane-3,5-dione
• CAS NO: 138332-82-8
• Molecular Weight: 415.963
• Mol File: 138332-82-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2R,6S,7R)-4-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.0^2,6]decane-3,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R,6S,7R)-4-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.0^2,6]decane-3,5-dione(138332-82-8)
• EPA Substance Registry System: (1S,2R,6S,7R)-4-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.0^2,6]decane-3,5-dione(138332-82-8)

Safety Data

• Hazardous Substances Data: 138332-82-8(Hazardous Substances Data)

Upstream product

• 14805-29-9 (3aR,4S,7R,7aS)?4,7?methylene?1H?isoindole?1,3(2H)-dione 
• 14166-28-0 exo-bicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride 
• 2746-19-2 (1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione 
• 99095-09-7 (1R,2S,3R,4S)-N-(4-bromobutyl)-2,3-bicyclo<2.2.1>heptanedicarboximide 
• 6640-24-0 N-(m-chlorophenyl)piperazine 

Relevant articles and documents

Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-b icyclo[2.2.1]heptanedicarboxime (Tandospirone) and related compounds

A series of cyclic imides bearing a ω-(4-aryl and 4-heteroaryl-1-piperazinyl)alkyl moieties was synthesized and tested in vivo for anxiolytic activity. The in vitro binding affinities of these compounds were also examined for 5-HT(1A) receptor sites. Structure-activity relationships within these series are discussed. One of these compounds, (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3- bicyclo[2.2.1]heptanedicarboximide (1: tandospirone), was found to be equipotent with buspirone in its anxiolytic activity and more anxio-selective than buspirone and diazepam. Tandospirone (1) is currently undergoing clinical evaluation as a selective anxiolytic agent.