6640-24-0

Basic information

• Product Name: 3-Chlorophenyl piperazine
• Synonyms: RARECHEM AH CK 0071;N-(3-CHLOROPHENYL)PIPERAZINE;TIMTEC-BB SBB003579;MCPP;1-(3-CHLORPHENYL)-PIPERAZINE;1-(3-CHLOROPHENYL)PIPERAZINE;3-chlorophenyl piperazine;AKOS BBS-00003580
• CAS NO: 6640-24-0
• Molecular Formula: C₁₀H₁₃ClN₂
• Molecular Weight: 196.68
• EINECS: 229-654-7
• Product Categories: Piperazines;PHARMACEUTICAL INTERMEDIATES;Piperidines, Piperidones, Piperazines;Piperaizine;API intermediates;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;FOR TRAZODONE'S PRODUCTION
• Mol File: 6640-24-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 210-214°C
• Boiling Point: 105 °C
• Flash Point: 157.2 °C
• Appearance: clear colorless to light yellow oily liquid
• Density: 1.193
• Vapor Pressure: 0.000112mmHg at 25°C
• Refractive Index: 1,598-1,600
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Sparingly)
• PKA: 8.85±0.10(Predicted)
• CAS DataBase Reference: 3-Chlorophenyl piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chlorophenyl piperazine(6640-24-0)
• EPA Substance Registry System: 3-Chlorophenyl piperazine(6640-24-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 6640-24-0(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to light yellow oily liquid

Uses

Different sources of media describe the Uses of 6640-24-0 differently. You can refer to the following data:
1. It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.
2. It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone (1,2,3). The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.

Definition

ChEBI: A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.

Hazard

A poison.

InChI:InChI=1/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2

Upstream product

• 108-42-9 3-chloro-aniline 
• 110-85-0 piperazine 
• 591-18-4 1-Bromo-3-iodobenzene 
• 108-37-2 1-bromo-3-chlorobenzene 
• 541-73-1 1,3-Dichlorobenzene 
• 625-99-0 3-iodochlorobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 186790-11-4 tert-butyl 4-(3-chlorophenyl)piperazine-1-carboxylate 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 
• 111-42-2 2,2'-iminobis[ethanol] 

Downstream Products

• 110148-38-4 1-[4-(3-chloro-phenyl)-piperazino]-3-(2-methoxy-phenoxy)-propan-2-ol 
• 185223-25-0 (1-Aza-bicyclo[2.2.2]oct-2-yl)-[4-(3-chloro-phenyl)-piperazin-1-yl]-methanone 
• 60987-60-2 9-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-1,3-dimethyl-6,7,8,9-tetrahydro-1H-pyrimido[2,1-f]purine-2,4-dione 

Relevant articles and documents

MONOACYLGLYCEROL LIPASE INHIBITORS

Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS

Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

Chrysin-piperazine conjugates as antioxidant and anticancer agents

Synthesis of 7-(4-bromobutoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one intermediate treating chrysin with 1,4-dibromobutane facilitated combination of chrysin with a wide range of piperazine moieties which were equipped via reacting the corresponding amines with bis(2-chloroethyl)amine hydrochloride in diethylene glycol monomethyl ether solvent. Free radical scavenging potential of prepared products was analyzed in vitro adopting DPPH and ABTS bioassay in addition to the evaluation of in vitro anticancer efficacies against cervical cancer cell lines (HeLa and CaSki) and an ovarian cancer cell line SK-OV-3 using SRB assay. Bearable toxicity of 7a-w was examined employing Madin-Darby canine kidney (MDCK) cell line. In addition, cytotoxic nature of the presented compounds was inspected utilizing Human bone marrow derived mesenchymal stem cells (hBM-MSCs). Overall, 7a-w indicated remarkable antioxidant power in scavenging DPPH+ and ABTS++, particularly analogs 7f, 7j, 7k, 7l, 7n, 7q, 7v, 7w have shown promising free radical scavenging activity. Analogs 7j and 7o are identified to be highly active candidates against HeLa and CaSki cell lines, whereas 7h and 7l along with 7j proved to be very sensitive towards ovarian cancer cell line SKOV-3. None of the newly prepared scaffolds showed cytotoxic nature toward hBM-MSCs cells. From the structure-activity point of view, nature and position of the electron withdrawing and electron donating functional groups on the piperazine core may contribute to the anticipated antioxidant and anticancer action. Different spectroscopic techniques (FT-IR, 1H NMR, 13C NMR, Mass) and elemental analysis (CHN) were utilized to confirm the desired structure of final compounds.