138336-33-1

Basic information

• Product Name: tert-Butyl 2-(Phenylsulfonyl)acetate
• Synonyms: tert-Butyl 2-(Phenylsulfonyl)acetate
• CAS NO: 138336-33-1
• Molecular Weight: 256.323
• Mol File: 138336-33-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: tert-Butyl 2-(Phenylsulfonyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 2-(Phenylsulfonyl)acetate(138336-33-1)
• EPA Substance Registry System: tert-Butyl 2-(Phenylsulfonyl)acetate(138336-33-1)

Safety Data

• Hazardous Substances Data: 138336-33-1(Hazardous Substances Data)

Upstream product

• 63006-68-8 tert-butyl (phenylthio)acetate 
• 873-55-2 sodium benzenesulfonate 
• 35059-50-8 t-butyl diazoacetate 
• 98-80-6 phenylboronic acid 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 38111-44-3 phenylzinc(II) bromide 
• 3959-23-7 benzenesulfonylacetic acid 
• 1360789-21-4 2-(phenylsulfonyl)-1-(2,2,6,6-tetramethylpiperidin-1-yl)ethanone 
• 75-65-0 tert-butyl alcohol 
• 108-98-5 thiophenol 

Downstream Products

• 1578219-50-7 3-(phenylsulfonyl)dihydro-2H-pyran-2,6(3H)-dione 

Relevant articles and documents

Method for preparing beta-carbonyl sulfone

The invention discloses a method for preparing beta-carbonyl sulfone. The preparation method comprises the following steps: by taking an alpha-carbonyl diazo compound and sodium arylsulfinate as reaction substrates, cheap silver nitrate as an optimal catalyst, 1, 10-phenanthroline as a ligand and potassium persulfate as an oxidant, carrying out coupling reaction in a mixed solvent of acetonitrileand water to obtain the beta-carbonyl sulfone compound. Compared with the prior art, the method has the advantages of wide reaction substrate range, short reaction time, high reaction yield, mild reaction conditions and the like. Non-toxic and harmless reagents are used as reaction raw materials, so that the method is harmless to the environment and meets the requirements of modern green chemicaldevelopment. Post-reaction treatment is simple, and separation and purification are facilitated. In addition, the reaction can realize gram-scale synthesis, and lays a foundation for practical application.

Pd(NHC)-catalyzed alkylsulfonylation of boronic acids: A general and efficient approach for sulfone synthesis

Robust N-heterocyclic carbene palladium complexes are highly efficient catalysts for direct alkylsulfonylation of (hetero)aryl- or alkenyl-boronic acids with potassium metabisulfite and (hetero)alkyl-halides. Among them, acenaphthoimidazolylidene palladium(ii) complexes exhibited the highest activities, and up to quantitative yields were obtained for diverse structurally distinct sulfones under very mild reaction conditions.

Acenaphthoimidazolylidene Gold Complex-Catalyzed Alkylsulfonylation of Boronic Acids by Potassium Metabisulfite and Alkyl Halides: A Direct and Robust Protocol to Access Sulfones

A robust acenaphthoimidazolylidene gold complex is demonstrated as a highly efficient catalyst in the direct alkylsulfonylation of boronic acids. Remarkably, a wide range of highly reactive and unreactive C-electrophiles were well-tolerated to produce various (hetero)aryl-alkyl, aryl-alkenyl, and alkenyl-alkyl sulfones in satisfactory yields with 5 mol % catalyst loading. Along with the steric properties of NHC ligands, the high catalytic activity of this gold complex suggests that the strong σ-donation of acenaphthoimidazolylidene also played a role in promoting this challenging redox-neutral catalytic process.