1383446-24-9

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 1245649-96-0 3-bromo-5-chloro-1H-pyrazolo[3,4-b]pyridine 
• 1245643-75-7 5-chloro-1H-pyrazolo[3,4-b]pyridin-3-amine 
• 126954-66-3 3-cyano-2,5-dichloropyridine 
• 75291-86-0 2,5-dichloropyridine-3-carboxamide 
• 1383446-23-8 5-chloro-3-iodo-1-trityl-1H-pyrazolo[3,4-b]pyridine 
• 1352395-64-2 5-chloro-3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 1240725-66-9 5-chloro-1H-pyrazolo[3,4-b]pyridine 
• 1383446-21-6 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)pyridine 
• 882679-90-5 5-chloro-2-fluoropyridine-3-carbaldehyde 
• 1480-65-5 2-fluoro-5-chloropyridine 
• 59782-85-3 2,5-dichloronicotinic acid 

Downstream Products

• 1383446-31-8 5-chloro-3-(5-fluoro-4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine 

Relevant academic research and scientific papers

INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF

Provided herein is inhibitors of influenza virus replication and uses thereof. Specifically, provided herein a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Influenza virus replication inhibitor and application thereof

The invention relates to an influenza virus replication inhibitor and application thereof, and particularly relates to a compound serving as an influenza virus replication inhibitor, a preparation method thereof, a pharmaceutical composition containing the compound, and application of the compound and the pharmaceutical composition to influenza treatment.

Influenza virus replication inhibitor and application thereof

The invention provides a type of compounds serving as an influenza virus replication inhibitor, a preparation method of the compounds, a pharmaceutical composition comprising the compounds, and application of the compounds and the pharmaceutical composition thereof in treatment of influenza.

INHIBITORS OF INFLUENZA VIRUSES REPLICATION

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.