1383480-07-6Relevant articles and documents
Discovery, design and synthesis of Y-shaped peroxisome proliferator- activated receptor δ agonists as potent anti-obesity agents in vivo
Ham, Jungyeob,Hwang, Hoosang,Kim, Euno,Kim, Jeong-Ah,Cho, Sung Jin,Ko, Jaeyoung,Lee, Woojin,Lee, Jaehwan,Holla, Harish,Banerjee, Joydeep,Kim, Seokho,Yang, Inho,Lee, Hyun Joo,Shin, Kyoungjin,Choi, Hyukjae,Nam, Sang-Jip,Tak, Jungae,Hahn, Dongyup,Oh, Taekyung,Won, Dong Hwan,Lee, Tae Gu,Choi, Jihye,Park, Mi Sun,Seok, Chaok,Chin, Jungwook,Kang, Heonjoong
, p. 190 - 202 (2012/08/13)
We have discovered and demonstrated the in vitro and in vivo PPARδ-selective activity of novel Y-shaped agonists. These compounds activated hPPARδ with EC50 values between 1 and 523 nM. Surprisingly, compounds 10a, 11d, 11e and 11f were the mos