636589-63-4

Basic information

• Product Name: 4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol
• Synonyms: 4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol
• CAS NO: 636589-63-4
• Molecular Weight: 395.469
• Mol File: 636589-63-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol(636589-63-4)
• EPA Substance Registry System: 4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol(636589-63-4)

Safety Data

• Hazardous Substances Data: 636589-63-4(Hazardous Substances Data)

Upstream product

• 317318-96-0 [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol 
• 72505-21-6 4-trifluoromethylbenzthioamide 
• 439134-78-8 5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole 
• 317318-97-1 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole 
• 95-48-7 ortho-cresol 
• 3774-53-6 2-methyl-4-thiocyanato-phenol 
• 60577-30-2 4-iodo-2-methyl-phenol 
• 2362-12-1 4-Bromo-2-methylphenol 
• 32281-01-9 4-mercapto-2-methylphenol 

Relevant articles and documents

Discovery, design and synthesis of Y-shaped peroxisome proliferator- activated receptor δ agonists as potent anti-obesity agents in vivo

We have discovered and demonstrated the in vitro and in vivo PPARδ-selective activity of novel Y-shaped agonists. These compounds activated hPPARδ with EC50 values between 1 and 523 nM. Surprisingly, compounds 10a, 11d, 11e and 11f were the mos

THIAZOLE COMPOUND (AS PPARδ) LIGAND AND PHARMACEUTICAL, COSMETIC AND HEALTH FOOD COMPRISED THEREOF

The present invention relates to a thiazole compound as a peroxisome proliferator activated receptor δ (PPARδ) activator or pharmaceutically acceptable salts thereof, and a pharmaceutical composition, a functional cosmetic composition, a health food, health beverages, a food additive and animal feeds containing the same.

A highly efficient synthesis of antiobestic ligand GW501516 for the peroxisome proliferator-activated receptor δ through in situ protection of the phenol group by reaction with a Grignard reagent

A new synthesis of an agonist for the peroxisome proliferator-activated receptor δ (PPARδ) GW501516 as a potential antiobesity drug is described. The synthetic route involves the in situ protection of the phenol group with a Grignard reagent and a regio-controlled one-pot reaction for the formation of a sulfide bond as the key step. Starting from commercially available 4-iodo-2-methylphenol, this approach affords GW501516 with an overall yield of 87%.