1383484-96-5

Basic information

• Product Name: 1-(2-phenyl-1H-benzimidazol-5-yl)ethanone oxime
• Synonyms: 1-(2-phenyl-1H-benzimidazol-5-yl)ethanone oxime
• CAS NO: 1383484-96-5
• Molecular Weight: 251.288
• Mol File: 1383484-96-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-phenyl-1H-benzimidazol-5-yl)ethanone oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-phenyl-1H-benzimidazol-5-yl)ethanone oxime(1383484-96-5)
• EPA Substance Registry System: 1-(2-phenyl-1H-benzimidazol-5-yl)ethanone oxime(1383484-96-5)

Safety Data

• Hazardous Substances Data: 1383484-96-5(Hazardous Substances Data)

Upstream product

• 1432-42-4 1-(4-amino-3-nitrophenyl)ethanone 
• 21304-39-2 1-(3,4-diaminophenyl)ethanone 
• 18640-58-9 3-nitro-4-bromoacetophenone 

Relevant articles and documents

5-Acetyl-2-arylbenzimidazoles as antiviral agents. Part 4

Within a project aimed at discovering new Flaviviridae inhibitors, new variously substituted 2-phenylbenzimidazoles were synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against viruses representatives of the three genera of the Flaviviridae family, i.e.: Pestivirus (BVDV), Flavivirus (YFV) and Hepacivirus (HCV). Title compounds were also tested against RNA viruses representative of other single-stranded, positive-sense (ssRNA+) negative-sense (RNA-), or double-stranded (dsRNA) genomes, as well as against representatives of two DNA virus families. Nine compounds showed activity against BVDV (EC50 = 0.8-8.0 μM), compound 31 being the most potent (EC50 = 0.80 μM) and selective (SI = CC50/EC50 = >100). When tested in an HCV replicon assay, compound 31 resulted again the most potent, displaying an EC50 value of 1.11 μM and an SI of 100. Besides inhibiting BVDV, two compounds (35 and 38) showed a moderate activity also against YFV (EC 50 = 13 μM). Interestingly, 35 was moderately active also against RSV (EC50 = 25 μM).