21304-39-2

Basic information

• Product Name: 3-4-diaminoacetophenone
• Synonyms: 3-4-diaminoacetophenone;Ethanone, 1-(3,4-diaminophenyl)- (9CI);1-(3,4-Diamino-phenyl)-ethanone
• CAS NO: 21304-39-2
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.1778
• Product Categories: AMINEPRIMARY
• Mol File: 21304-39-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 132-133 °C(Solv: benzene (71-43-2))
• Boiling Point: 384.0±22.0 °C(Predicted)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.98±0.10(Predicted)
• CAS DataBase Reference: 3-4-diaminoacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-4-diaminoacetophenone(21304-39-2)
• EPA Substance Registry System: 3-4-diaminoacetophenone(21304-39-2)

Safety Data

• Hazardous Substances Data: 21304-39-2(Hazardous Substances Data)

Usage

General Description

3-4-diaminoacetophenone, also known as 4-aminoacetophenone, is a chemical compound with the molecular formula C8H10N2O. It is a pale yellow solid that is used in the synthesis of pharmaceuticals and other organic compounds. 3-4-diaminoacetophenone is commonly used as a reagent for the analysis of amino acids and other biological samples, as well as in the manufacturing of dyes and pigments. It is also used in the production of UV absorbers and stabilizers for plastics and other materials to protect them from degradation by sunlight. Additionally, it has applications in the production of photoresists and in the field of organic synthesis. Overall, 3-4-diaminoacetophenone plays a crucial role in various industrial processes and scientific research.

Upstream product

• 1432-42-4 1-(4-amino-3-nitrophenyl)ethanone 
• 7418-44-2 1-(4-acetylamino-3-nitrophenyl)ethanone 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 99-92-3 p-aminobenzophenone 

Downstream Products

• 146519-40-6 1-(1H-benzo[d][1,2,3]triazol-5-yl)ethanone 
• 13535-47-2 5-Acetyl-2-methyl-benzimidazol 
• 67469-03-8 5-Acetyl-2-aminobenzimidazol 
• 1224878-09-4 5-acetyl-2-(2,4-dimethoxyphenyl)-1H-benzimidazole 
• 1224878-10-7 5-acetyl-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole 
• 83570-42-7 1-(quinoxalin-6-yl)ethan-1-one 
• 1368421-79-7 2-(cyclohexyl)-5-acetyl-1H-benzimidazole 
• 1383485-04-8 2-(1-(2-(4-trifluoromethylphenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarboxamide 
• 1383485-05-9 2-(1-(2-(4-methoxyphenyl)-1H-benzimidazol-5 yl)ethylidene)hydrazinecarboxamide 
• 1383485-03-7 2-(1-(2-(4-chlorophenyl)-1H-benzimidazol-5-yl)ethylidene)hydrazinecarboxamide 
• 1383485-02-6 2-(1-(2-phenyl-1H-benzimidazol-5-yl)ethylidene)hydrazinecarboxamide 
• 1383485-01-5 1-(2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-5-yl)ethanone oxime 
• 1383485-00-4 1-(2-(2,4-dimethoxyphenyl)-1H-benzimidazol-5-yl)ethanone oxime 
• 1383484-99-8 1-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)ethanoneoxime 

Relevant articles and documents

1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation

Glycogen synthase kinase 3 (GSK-3)has become known for its multifactorial involvement in the pathogenesis of Alzheimer's disease. In this study, a benzothiazole- and benzimidazole set of 1-aryl-3-(4-methoxybenzyl)ureas were synthesised as proposed Cys199-targeted covalent inhibitors of GSK-3β, through the incorporation of an electrophilic warhead onto their ring scaffolds. The nitrile-substituted benzimidazolylurea 2b (IC50 = 0.086 ± 0.023 μM)and halomethylketone-substituted benzimidazolylurea 9b (IC50 = 0.13 ± 0.060 μM)displayed high GSK-3β inhibitory activity, in comparison to reference inhibitor AR-A014418 (1, IC50 = 0.072 ± 0.043)in our assay. The results suggest further investigation of 2b and 9b as potential covalent inhibitors of GSK-3β, since a targeted interaction might provide improved kinase-selectivity.

4-(Benzoimidazol-2-yl)-thiazole Compounds and Related Aza Derivatives

The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4′, R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

5-Acetyl-2-arylbenzimidazoles as antiviral agents. Part 4

Within a project aimed at discovering new Flaviviridae inhibitors, new variously substituted 2-phenylbenzimidazoles were synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against viruses representatives of the three genera of the Flaviviridae family, i.e.: Pestivirus (BVDV), Flavivirus (YFV) and Hepacivirus (HCV). Title compounds were also tested against RNA viruses representative of other single-stranded, positive-sense (ssRNA+) negative-sense (RNA-), or double-stranded (dsRNA) genomes, as well as against representatives of two DNA virus families. Nine compounds showed activity against BVDV (EC50 = 0.8-8.0 μM), compound 31 being the most potent (EC50 = 0.80 μM) and selective (SI = CC50/EC50 = >100). When tested in an HCV replicon assay, compound 31 resulted again the most potent, displaying an EC50 value of 1.11 μM and an SI of 100. Besides inhibiting BVDV, two compounds (35 and 38) showed a moderate activity also against YFV (EC 50 = 13 μM). Interestingly, 35 was moderately active also against RSV (EC50 = 25 μM).