1383531-60-9Relevant academic research and scientific papers
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening
Lee, Angeline C.-H.,Ramanujulu, Pondy Murugappan,Poulsen, Anders,Williams, Meredith,Blanchard, Stephanie,Ma, Diana M.,Bonday, Zahid,Goh, Kay Lin,Goh, Kee Chuan,Goh, Miah Kiat,Wood, Jeanette,Dymock, Brian W.
supporting information; experimental part, p. 4023 - 4027 (2012/07/03)
Ligand efficient fragments binding to PDK1 were identified by an NMR fragment-based screening approach. Computational modeling of the fragments bound to the active site led to the design and synthesis of a series of novel 6,7-disubstituted thienopyrimidin
