1383533-25-2Relevant academic research and scientific papers
A facile access to 3,5-disubstituted oxazolones featuring a Cu-catalyzed cyclization of N-alkynyl tert-butyl carbamates
Lu, Zenghui,Yang, Zhaozhen,Cui, Weijian,Zhu, Gangguo
experimental part, p. 636 - 638 (2012/07/28)
Using cheap and readily accessible CuCl as the catalyst, an operationally simple and efficient method for the synthesis of 3,5-disubstituted oxazolones has been realized by the cyclization of N-alkynyl tert-butyl carbamates. The reaction proceeds under mild reaction conditions and shows good functional group compatibility.
Approach to highly functionalized oxazolones by a Pd-catalyzed cyclization of N-alkynyl tert-butyloxycarbamates
Lu, Zenghui,Xu, Xiaowei,Yang, Zhaozhen,Kong, Lichun,Zhu, Gangguo
supporting information; experimental part, p. 3433 - 3436 (2012/08/08)
A mild and operationally simple approach to highly functionalized oxazolones has been developed, which involves an intramolecular oxypalladation of N-alkynyl tert-butyloxycarbamates, followed by either protonolysis of the alkenyl C-Pd bond to afford 3,5-disubstituted oxazolones or allylation with allyl halides in the presence of Ag2CO3 to generate 3,4,5-trisubstituted oxazolones, respectively.
