1383537-49-2Relevant academic research and scientific papers
Development of Selective Estrogen Receptor Modulator (SERM)-Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7-Oxabicyclo[2.2.1]hept-5-ene Scaffold Core Ligands
Zheng, Yangfan,Zhu, Manghong,Srinivasan, Sathish,Nwachukwu, Jerome C.,Cavett, Valerie,Min, Jian,Carlson, Kathryn E.,Wang, Pengcheng,Dong, Chune,Katzenellenbogen, John A.,Nettles, Kendall W.,Zhou, Hai-Bing
, p. 1094 - 1100 (2012)
Previously, we discovered estrogen receptor (ER) ligands with a novel three-dimensional oxabicyclo[2.2.1]heptene core scaffold and good ER binding affinity act as partial agonists via small alkyl ester substitutions on the bicyclic core that indirectly mo
