138356-91-9

Upstream product

• 123-75-1 pyrrolidine 
• 15761-38-3 L-N-Boc-Ala 

Downstream Products

• 138356-96-4 2-(3,4-Dichloro-phenyl)-N-methyl-N-((R)-1-methyl-2-pyrrolidin-1-yl-ethyl)-acetamide 
• 138356-30-6 [2-(3,4-Dichloro-phenyl)-ethyl]-methyl-((R)-1-methyl-2-pyrrolidin-1-yl-ethyl)-amine 
• 138357-19-4 N-<1-(1-pyrrolidinyl)-2(R)-propyl>-N-methyl-N'-<(S)-α-methylbenzyl>urea 
• 1415969-04-8 (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl-ammonium chloride 

Relevant academic research and scientific papers

Direct synthesis of amides from carboxylic acids and amines using B(OCH2CF3)3

B(OCH2CF3)3, prepared from readily available B2O3 and 2,2,2-trifluoroethanol, is as an effective reagent for the direct amidation of a variety of carboxylic acids with a broad range of amines. In most cases, the amide products can be purified by a simple filtration procedure using commercially available resins, with no need for aqueous workup or chromatography. The amidation of N-protected amino acids with both primary and secondary amines proceeds effectively, with very low levels of racemization. B(OCH2CF3)3 can also be used for the formylation of a range of amines in good to excellent yield, via transamidation of dimethylformamide.