1383568-91-9

Upstream product

• 4754-27-2 1-(3-Pyridyl)ethanol 
• 1312678-77-5 (S)-1-(N-(4-methoxybenzyl)-1,2,5,6-tetrahydropyridin-3-yl)ethanol 
• 1383568-86-2 (S)-1-(4-methoxybenzyl)-5-(1-((tributylstannyl)methoxy)ethyl)-1,2,3,6-tetrahydropyridine 
• 1383568-87-3 (S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)methanol 
• 1312678-79-7 (+/-)-1-(N-(4-methoxybenzyl)-1,2,5,6-tetrahydropyridin-3-yl)ethanol 
• 1383568-89-5 (S,E)-3-ethylidene-1-(4-methoxybenzyl)piperidine-4-carbaldehyde 
• 1383568-90-8 ((S,E)-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanol 
• 40900-03-6 1-(benzenesulfonyl)-2-lithioindole 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1383568-93-1 (S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone 

Relevant academic research and scientific papers

SYNTHESIS OF CONOLIDINE AND DISCOVERY OF A POTENT NON-OPIOID ANALGESIC FOR PAIN

The first de novo synthetic pathway to the exceptionally rare C5-nor stemmadenine natural product, conolidine, and the first asymmetric synthesis of any member of this natural product class arc described. C5-nor stemmadenine compositions are also describe

Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain

Management of chronic pain continues to represent an area of great unmet biomedical need. Although opioid analgesics are typically embraced as the mainstay of pharmaceutical interventions in this area, they suffer from substantial liabilities that include