1383572-82-4

Basic information

• Product Name: C₁₂H₁₀ClNOS
• CAS NO: 1383572-82-4
• Molecular Weight: 251.737
• Mol File: 1383572-82-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₀ClNOS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₀ClNOS(1383572-82-4)
• EPA Substance Registry System: C₁₂H₁₀ClNOS(1383572-82-4)

Safety Data

• Hazardous Substances Data: 1383572-82-4(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 332370-74-8 2-Chloro-thiophene-3-carbonyl chloride 
• 53935-71-0 2-chlorothiophene-3-carboxylic acid 

Downstream Products

• 1383572-75-5 N-benzyl-2-hydroxythiophene-3-carboxamide 

Relevant articles and documents

A highly efficient copper-catalyzed method for the synthesis of 2-hydroxybenzamides in water

An efficient copper-catalyzed synthetic method for the preparation of 2-hydroxybenzamides is described for the first time from 2-chlorobenzamide substrates using copper iodide/1,10-phenanthroline and a base, potassium hydroxide, in neat water. By using this reaction, a series of 2-hydroxybenzamides with functional groups such as fluoro, chloro, iodo, methoxy, amide, and alcohol have been obtained in 33-96% yield. Other aromatic 2-chloroarylamides such as naphthalene, pyridine, and thiophene are found to be equally compatible to the reaction. It is proposed that the reaction proceed via formation of copper-amide complex, which may facilitate the hydroxylation in water. Overall, the first report on copper-catalyzed hydroxylation reaction in water and first catalytic route for the synthesis of 2-hydroxybenzamides is presented. Simple purification procedure and convenience of employing low-cost reagents in neat water make this method practical and economical for the synthesis of 2-hydroxybenzamides. Georg Thieme Verlag Stuttgart · New York.