1383608-85-2Relevant academic research and scientific papers
Synthesis and anti-oxidant activity of (5E,9E)-16-(substituted)-7,8- dihydro-16λ5-dibenzo[d,l][1,3,7,10,2]- dioxadiazaphosphacyclotridecine-16-ones
Reddy, Chinta Raveendra,Rani, Chinthaparthi Radha,Sekhar, Kuruva Chandra,Reddy, Gangireddy Chandra Sekhar,Raju, Chamarthi Naga
, p. 495 - 502 (2012/08/29)
A new class of biologically active 13-membered phosphorus-macroheterocycles (6a-l) were conveniently synthesized from 1,2-bis(salicylidene amino)-phenylene (1), by treating with phosporusoxychloride (3) and followed by reacting with various aromatic thiols and amines (5f-l) in one path, and in another path 1 was directly treated with various phosphorodichloridates (2a-e) in the presence of triethylamine at 0-10°C under N2 atmosphere in THF. All the title compounds were confirmed by analytical and spectral data (IR, 1H-, 13C-, 31P-NMR, and mass spectra) and screened for anti-oxidant activity. Among these compounds, 6k, 6e, and 6l containing nitro, fluoro, and chloro groups as substituents on the phenyl ring exhibited high anti-oxidant activity with effective inhibitory concentration (IC50) values.
