94-93-9Relevant articles and documents
Synthesis and spectral investigation (1H and 13C) of Tetradentate schiff base Ligands for the preparation of post transition bimetallic complexes of antimicrobial importance
Zahoor, Ameer Fawad,Yousaf, Muhammad,Pervaiz, Muhammad,Anjum, Anbreen,Ali, Kulsoom Ghulam,Zahid, Faisal Maqbool,Ahmad, Sajjad,Bukhari, Shazia Anwer,Parveen, Bushra
, p. 841 - 845 (2014)
A tetradentate Schiff base ligand 2-(bis-2-hydroxylphenylidene)-1,2- diiminoethanne (L) was synthesized and then its structure was investigated by 1H NMR and 13C NMR techniques. The ligand and its bimetallic complexes were screened in vitro for
Synthesis, characterization and catalytic activity of Fe(Salen) intercalated α-zirconium phosphate for the oxidation of cyclohexene
Khare, Savita,Chokhare, Rajendra
, p. 83 - 92 (2011)
Iron(III)-Salen intercalated α-zirconium phosphate, abbreviated as {α-ZrP·Fe(Salen)} was synthesized in situ by the flexible ligand method. The resulting compound was characterized by BET surface area, X-ray diffraction, scanning electron microscopy, ener
Synthesis, characterization and biological studies of bis-{μ-2,2'- [ethane-1,3-diylbis(nitrilomethylidyne)]diphenolato}dicopper(II) Using Triple Component Solvent System
Yousaf, Muhammad,Pervaiz, Muhammad,Zahoor, Ameer Fawad,Hussain, Abdullah Ijaz,Khosa, Muhammad Kaleem Khan,Ashraf, Sadia,Sagir, Muhammad,Ashar-Uz-Zaman,Shehzad, Khurram
, p. 521 - 524 (2013)
The bis-{μ-2,2'-[ethane-1,3-diyl-bis(nitrilomethylidyne)]diphenolato} dicopper(II) with the molecular formula [Cu2(C16H 14N2O2)2] shows the dimeric complex. Distorted square pyramidal geome
First examples of near-infrared luminescent poly(methyl methacrylate)-supported metallopolymers based on Zn2Ln-arrayed schiff base complexes
Miao, Tie-Zheng,Feng, Wei-Xu,Zhang, Zhao,Su, Pei-Yang,Lü, Xing-Qiang,Song, Ji-Rong,Fan, Dai-Di,Wong, Wai-Kwok,Jones, Richard A.,Su, Cheng-Yong
, p. 2839 - 2848 (2014)
The first examples of Wolf Type II Zn2Ln-containing metallopolymers poly{MMA-co-[Zn2(L)2(4-vp) 2Ln(NO3)3]} (Ln = La, Nd, Yb, Er, Gd; H 2L = N,N′-bis(salicylidene)ethylene-1,2-diamine; 4-vp = 4-vinylpyridine; MMA = methyl methacrylate) are obtained from the controlled copolymerization of heterotrinuclear Zn2Ln-arrayed complexes [Zn 2(L)2(4-vp)2Ln(NO3)3] (Ln = La, 1; Ln = Nd, 2; Ln = Yb, 3; Ln = Er, 4; Ln = Gd, 5) with MMA. The strong and characteristic near-infrared (NIR) luminescent Ln3+-centered emission for each of the PMMA-supported poly{MMA-co-[Zn2(L) 2(4-vp)2Ln(NO3)3]} (Ln = Nd, Yb, Er) hybrid materials is retained with somewhat higher intrinsic quantum yields than those of the respective Zn2Ln-arrayed complex. Especially for poly(MMA-co-3), which has more efficient sensitization from both ligand-centered singlet (1LC) and triplet (3LC) states of the chromophores, the concentration self-quenching of Yb3+-based NIR luminescence could be effectively prevented. The first examples of Wolf Type II near-infrared-luminescent Zn2Ln-containing metallopolymers poly{MMA-co-[Zn2(L)2(4-vp)2Ln(NO 3)3]} (H2L = N,N′-bis(salicylidene) ethylene-1,2-diamine; Ln = La, Nd, Yb, Er, Gd; MMA = methyl methacrylate; 4-vp = 4-vinylpridine) are obtained from the controlled copolymerization of MMA with a series of Zn2Ln-arrayed Schiff base complexes [Zn 2(L)2(4-vp)2Ln(NO3)3]. Copyright
C-C and C-H coupling reactions by Fe3O4/KCC-1/APTPOSS supported palladium-salen-bridged ionic networks as a reusable catalyst
Hassankhani, Asadollah,Sadeghzadeh, Seyed Mohsen,Zhiani, Rahele
, p. 8761 - 8769 (2018)
This study investigates the potential application of an efficient, easily recoverable and reusable magnetically separable Fe3O4/KCC-1/APTPOSS nanoparticle-supported salen/Pd(ii) catalyst for C-C and C-H cross-couplings. The Fe3O4/KCC-1/APTPOSS/salen/Pd(ii) MNPs were thoroughly characterized by using TEM, FE-SEM, TGA, XRD, VSM, FT-IR, ICP-MS, and BET. This observation was exploited in the direct and selective chemical reaction of 2-acetyl-benzaldehyde with cyclopentadiene for the synthesis of pentafulvene. The recycled catalyst has been analyzed by ICP-MS showing only minor changes in the morphology after the reaction, thus confirming the robustness of the catalyst.
Salen copper (II) complex encapsulated in y zeolite: An effective heterogeneous catalyst for TCF pulp bleaching using peracetic acid
Zhang, Na,Zhou, Xue-Fei
, p. 66 - 72 (2012)
Cu(salen) and NaY encapsulated complexes, were synthesized by the "impregnation" (Cu(salen)/Y-IM) and flexible ligand "ship-in-a-botttle" (Cu(salen)/Y-SB) method. The resulting compounds were characterized by XRD, FTIR, DR UV-vis, BET. The encapsulated co
Synthesis, crystal structures, and superoxide dismutase activity of two new multinuclear manganese(III)-salen-4,4′-bipyridine complexes
Deawati, Yusi,Onggo, Djulia,Mulyani, Irma,Hastiawan, Iwan,Kurnia, Dikdik,L?nnecke, Peter,Schmorl, Sara,Kersting, Berthold,Hey-Hawkins, Evamarie
, p. 353 - 357 (2018)
Manganese(III)-salen complexes have been reported as superoxide dismutase mimics (mSOD) that can scavenge superoxide anion radicals. They are mononuclear complexes with a variety of salen ligands. Here, two new multinuclear manganese(III)-salen complexes
Solution behaviour of (N,N'-ethylenebis(salicylideneiminato))- iron(III) chloride in aqueous methanol at 298.15, 303.15 and 313.15 K
Brahman, Dhiraj,Sinha, Biswajit
, p. 225 - 239 (2014)
In this study partial molar volumes (φ0v ) and viscosity B-coefficients of (N,N'-ethylene-bis(salicylideneiminato))iron(III) chloride, abbreviated as FeIII(salen)Cl, in different aqueous methanolic solutions were determine
Synthesis characterization and biological screening of tri-benzyltin(IV) complexes of some Schiff bases
Rehman, Wajid,Badshah, Amin,Baloch, Musa Kaleem,Ali, Saqib,Hameed, Gulzar,Khan, Khalid M.
, p. 929 - 934 (2004)
Synthesis and characterization of some novel di and tri-benzyltin(IV) complexes of some Schiff bases are reported. The 1H-NMR, 13C-NMR, 119Sn-NMR, IR, Elemental Analysis and 119Sn Moessauber studies are made for structural determination. Spectroscopic data reveals that the ligand molecule is bound to the tin atom through oxygen. On the basis of spectroscopic data tetrahedral geometry is proposed for the synthesized compounds. The synthesized compounds have been tested against various microorganisms. The results obtained show that the synthesized compounds have promising activity against all the tested micro-organisms.
Synthesis and characterization of bimetallic post transition complexes for antimicrobial activity
Pervaiz,Yousaf,Sagir,Mushtaq,Naz,Ullah,Mushtaq
, p. 546 - 552 (2015)
Antimicrobial and antibacterial activities of bimetallic complexes are very important in variety of biological mechanisms. In this research work, a Schiff base ligand 2-(bis-2-hydroxylphenylidene)-1,2-iminoethane was prepared by condensation reaction betw
A zig-zag end-to-end azido bridged MnIII 1-D coordination polymer: Spectral elucidation, magnetism, redox study and biological activity
Das, Kuheli,Datta, Amitabha,Beyene, Belete B.,Massera, Chiara,Garribba, Eugenio,Sinha, Chittaranjan,Akitsu, Takashiro,Tanka, Shinnosuke
, p. 315 - 322 (2017)
A zig-zag one-dimensional Mn(III) coordination polymer, {[C6H4(O)CHN(CH2)2NCH(O)C6H4]Mn(N3)}n (1) has been synthesized reacting a manganese salt with the Schiff base precursor H2L, obtained condensing salicyldehyde and ethylenediamine. The compound has been characterized by IR, UV–Vis and EPR spectroscopy. Single crystal X-ray diffraction studies have revealed that the Mn atom possesses a distorted octahedral environment and the metals connected by end-to-end azido ligands lead to the formation of 1-D zig-zag molecular chains. Temperature dependent magnetic studies have shown the presence of weak anti-ferromagnetic coupling among the Mn centers. Cyclic voltammetry has evidenced the presence of a reversible redox couple for the Mn3+/Mn2+ system. Both the ligand and complex 1 exhibit anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and M. tuberculosis H37Ra ATCC 25177 strains. The cytotoxicity study on different human cancer cell lines (Caco 2, MCF7 and A549) suggests that complex 1 has potential anticancer properties.
Synthesis, dft calculations, antiproliferative, bactericidal activity and molecular docking of novel mixed-ligand salen/8-hydroxyquinoline metal complexes
Abdalla, Ehab M.,Abdel Rahman, Laila H.,Al-Farhan, Badriah Saad,Basha, Maram T.,El-Ezz, Doaa Abou,El-Saghier, Ahmed M. M.,Marzouk, Adel A.,Shehata, Mohamed R.
, (2021/08/13)
Despite the common use of salens and hydroxyquinolines as therapeutic and bioactive agents, their metal complexes are still under development. Here, we report the synthesis of novel mixed-ligand metal complexes (MSQ) comprising salen (S), derived from (2,2′-{1,2-ethanediylbis [nitrilo(E) methylylidene]}diphenol, and 8-hydroxyquinoline (Q) with Co(II), Ni(II), Cd(II), Al(III), and La(III). The structures and properties of these MSQ metal complexes were investigated using molar conductivity, melting point, FTIR,1H NMR,13C NMR, UV–VIS, mass spectra, and thermal analysis. Quantum calculation, analytical, and experimental measurements seem to suggest the proposed structure of the compounds and its uncommon monobasic tridentate binding mode of salen via phenolic oxygen, azomethine group, and the NH group. The general molecular formula of MSQ metal complexes is [M(S)(Q)(H2O)] for M (II) = Co, Ni, and Cd or [M(S)(Q)(Cl)] and [M(S)(Q)(H2O)]Cl for M(III) = La and Al, respectively. Importantly, all prepared metal complexes were evaluated for their antimicrobial and anticancer activities. The metal complexes exhibited high cytotoxic potency against human breast cancer (MDA-MB231) and liver cancer (Hep-G2) cell lines. Among all MSQ metal complexes, CoSQ and LaSQ produced IC50 values (1.49 and 1.95 μM, respectively) that were comparable to that of cisplatin (1.55 μM) against Hep-G2 cells, whereas CdSQ and LaSQ had best potency against MDA-MB231 with IC50 values of 1.95 and 1.43 μM, respectively. Furthermore, the metal complexes exhibited significant antimicrobial activities against a wide spectrum of both Gram-positive and-negative bacterial and fungal strains. The antibacterial and antifungal efficacies for the MSQ metal complexes, the free S and Q ligands, and the standard drugs gentamycin and ketoconazole decreased in the order AlSQ > LaSQ > CdSQ > gentamycin > NiSQ > CoSQ > Q > S for antibacterial activity, and for antifungal activity followed the trend of LaSQ > AlSQ > CdSQ > ketoconazole > NiSQ > CoSQ > Q > S. Molecular docking studies were performed to investigate the binding of the synthesized compounds with breast cancer oxidoreductase (PDB ID: 3HB5). According to the data obtained, the most probable coordination geometry is octahedral for all the metal complexes. The molecular and electronic structures of the metal complexes were optimized theoretically, and their quantum chemical parameters were calculated. PXRD results for the Cd(II) and La(III) metal complexes indicated that they were crystalline in nature.
Synthesis, Characterization, Theoretical Studies, and Antimicrobial/Antitumor Potencies of Salen and Salen/Imidazole Complexes of Co (II), Ni (II), Cu (II), Cd (II), Al (III) and La (III)
Abdalla, Ehab M.,Abdel Rahman, Laila H.,Abdelhamid, Antar A.,Shehata, Mohamed R.,Alothman, Asma A.,Nafady, Ayman
, (2020/07/13)
Although salens and imidazoles are well-studied motifs among bioactive and therapeutic agents, their properties when combined in transition metal complexes are not well developed. To explore the structure/reactivity of this class of compounds, a salen-based ligand, namely (2,2′-{1,2-ethanediylbis[nitrilo(E)methylylidene]}diphenol, S), and its binary (MS) and ternary (MSI) complexes (I = imidazole; M = Co (II), Ni (II), Cu (II), Cd (II), Al (III), and La (III)) have been synthesized and fully characterized by standard physicochemical and theoretical methods. Evidence from structural analysis tools along with DFT modeling revealed an unusual monobasic tridentate salen binding mode, involving the phenolic oxygen, the nitrogen of the azomethine group, and NH group formed via phenol-to-cyclohexadienone tautomerization, giving rise to a general molecular formula of MSI complexes as [M(S)(I)2(Cl)] for M (II) = Co, Ni, Cu and Cd or [M(S)(I)(Cl)2] for M (III) = Al and La, respectively. The antimicrobial activities of S, MS, and MSI were screened against several bacterial and fungal strains. Of all tested complexes, CdS and CuSI were the most effective antimicrobials, giving larger inhibition zones than the reference antibiotics. The antimicrobial efficacy for the MS complexes follows the order: CdS > gentamicin > CuS > NiS > CoS > LaS > AlS > S, whereas MSI complex, potencies are ordered as CuSI > gentamicin > CdSI >NiSI > CoSI > LaSI > AlSI > S. In vitro cytotoxicity screening of MSI complexes disclosed that both CuSI and CdSI exhibited higher activity against human liver (Hep-G2) and breast (MDA-MB231) carcinoma cell lines than the reference (cisplatin) drug. The satisfactory bioactivities observed for several of these compounds supports the underlying design idea for combining important bioactive motifs for possible therapeutic benefit.
