1383610-33-0

Basic information

• Product Name: (2S)-4-hydroxybutan-2-yl 4-methoxy-2-(methoxymethoxy)-6-[(1E)-3-oxoprop-1-en-1-yl]benzoate
• Synonyms: (2S)-4-hydroxybutan-2-yl 4-methoxy-2-(methoxymethoxy)-6-[(1E)-3-oxoprop-1-en-1-yl]benzoate
• CAS NO: 1383610-33-0
• Molecular Weight: 338.357
• Mol File: 1383610-33-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-4-hydroxybutan-2-yl 4-methoxy-2-(methoxymethoxy)-6-[(1E)-3-oxoprop-1-en-1-yl]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-4-hydroxybutan-2-yl 4-methoxy-2-(methoxymethoxy)-6-[(1E)-3-oxoprop-1-en-1-yl]benzoate(1383610-33-0)
• EPA Substance Registry System: (2S)-4-hydroxybutan-2-yl 4-methoxy-2-(methoxymethoxy)-6-[(1E)-3-oxoprop-1-en-1-yl]benzoate(1383610-33-0)

Safety Data

• Hazardous Substances Data: 1383610-33-0(Hazardous Substances Data)

Upstream product

• 532394-23-3 5-hydroxy-7-methoxy-2,2-dimethyl-benzo[1,3]dioxin-4-one 
• 1383610-40-9 C₁₁H₁₄O₆ 
• 1383610-39-6 C₁₃H₁₆O₆ 

Downstream Products

• 1383610-34-1 (2S)-4-hydroxybutan-2-yl 2-[(1E)-3-[(tert-butyldimethylsilyl)oxy]-3-oxoprop-1-en-1-yl]-4-methoxy-6-(methoxymethoxy)benzoate 
• 1383610-35-2 (2S)-4-oxobutan-2-yl 2-[(1E)-3-[(tert-butyldimethylsilyl)oxy]-3-oxoprop-1-en-1-yl]-4-methoxy-6-(methoxymethoxy)benzoate 
• 1383610-38-5 (2E)-3-[2-({[(2S,4E)-7-{[(tert-butoxy)carbonyl]amino}-6-oxohept-4-en-2-yl]oxy}carbonyl)-5-methoxy-3-(methoxymethoxy)phenyl]prop-2-enoic acid 

Relevant articles and documents

Synthesis, kinase activity and molecular modeling of a resorcylic acid lactone incorporating an amide and a trans-enone in the macrocycle

Details for the synthesis of a resorcylic acid lactone (RAL) incorporating a trans-enone and an amide in the macrocyclic ring are provided herein. The sequence included the assembly of three fragments by esterification, olefination, and lactamization. The RAL with the lactam was less potent as an inhibitor of kinases than other RALs investigated. The biological results were rationalized by docking and molecular dynamics simulations of the lactam bound to human ERK2 and comparison with hypothemycin.