1383675-98-6Relevant academic research and scientific papers
Phosphine-phosphite ligands: Chelate ring size vs. activity and enantioselectivity relationships in asymmetric hydrogenation
Farkas, Gergely,Balogh, Szabolcs,Madarasz, Jozsef,Szoellsy, Aron,Darvas, Ferenc,Uerge, Laszlo,Gouygou, Maryse,Bakos, Jozsef
experimental part, p. 9493 - 9502 (2012/09/11)
A series of new phosphine-phosphite ligands P(C)nOP (n = 1-4) have been synthesized and used for rhodium-catalyzed asymmetric hydrogenation of prochiral olefins in order to study the effect of the chelate ring size. Excellent ees (up to 97.5%) were obtained in the hydrogenation of dimethyl itaconate and an increase of activity and enantioselectivity was observed in the hydrogenation of (Z)-α-acetamidocinnamic acid methyl ester with the increasing length of the backbone of the ligands.
