138371-54-7

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-(1-oxo-3-phenylpropyl)-, 1,1-dimethylethyl ester
• CAS NO: 138371-54-7
• Molecular Formula: C18H25NO3
• Molecular Weight: 303.401
• Mol File: 138371-54-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-(1-oxo-3-phenylpropyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-(1-oxo-3-phenylpropyl)-, 1,1-dimethylethyl ester(138371-54-7)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-(1-oxo-3-phenylpropyl)-, 1,1-dimethylethyl ester(138371-54-7)

Safety Data

• Hazardous Substances Data: 138371-54-7(Hazardous Substances Data)

Upstream product

• 138371-68-3 1-N-tert-butoxycarbonylamino-4-phenyl-2-butanone 
• 109-70-6 1.3-chlorobromopropane 
• 501-52-0 3-Phenylpropionic acid 
• 149682-75-7 (N-(1,1-dimethylethoxycarbonyl)pyrrolidin-2-yl)boronic acid 
• 645-45-4 hydrocinnamic acid chloride 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 31419-53-1 1-amino-4-phenyl-2-butan-one hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 138371-66-1 3-Phenyl-1-pyrrolidin-2-yl-propan-1-one; hydrochloride 

Relevant articles and documents

Direct Conversion of Carboxylic Acids to Alkyl Ketones

An efficient and mild method for acyl-Csp3 bond formation based on the direct conversion of carboxylic acids has been established. This protocol is enabled by the synergistic, Ir-photoredox/nickel catalytic cross-coupling of in situ activated c

Fragment Couplings via CO2 Extrusion-Recombination: Expansion of a Classic Bond-Forming Strategy via Metallaphotoredox

In this study we demonstrate that molecular fragments, which can be readily coupled via a simple, in situ RO-C=OR bond-forming reaction, can subsequently undergo metal insertion-decarboxylation-recombination to generate Csp2-Csp3 bonds when subjected to metallaphotoredox catalysis. In this embodiment the conversion of a wide variety of mixed anhydrides (formed in situ from carboxylic acids and acyl chlorides) to fragment-coupled ketones is accomplished in good to high yield. A three-step synthesis of the medicinal agent edivoxetine is also described using this new decarboxylation-recombination protocol.