1383733-48-9

Upstream product

• 170848-34-7 N-t-butoxycarbonyl-3-iodo-D-alanine methyl ester 
• 1383733-47-8 tert-butyl {(3S,5S)-5-(2,3-difluorophenyl)-2-[(2-hydroxy-3-methoxy-3-methylbutyl)imino]piperidin-3-yl}carbamate 
• 1383733-43-4 tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-thioxopiperidin-3-yl]carbamate 
• 1375541-88-0 tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate 
• 170848-34-7 methyl 2-[(tert-butoxycarbonyl)amino]-3-iodopropanoate 
• 145689-34-5 2-(2,3-difluorophenyl)acetonitrile 

Downstream Products

• 1383733-49-0 (6S,8S)-6-(2,3-difluorophenyl)-3-(2-methoxypropan-2-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-amine 
• 1383733-27-4 (2R)-N-[(6S,8S)-6-(2,3-difluorophenyl)-3-(2-methoxypopan-2-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl]-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carboxamide 
• 1433985-98-8 (6S)-N-[(6S,8S)-6-(2,3-difluorophenyl)-3-(2-methoxypropan-2-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide 

Relevant academic research and scientific papers

FUSED HETEROCYCLIC AZAINDANE CARBOXAMIDE CGRP RECEPTOR ANTAGONISTS

The present invention is directed to fused heterocyclic azaindane carboxamide derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

FUSED HETEROCYCLIC INDANE CARBOXAMIDE CGRP RECEPTOR ANTAGONISTS

The present invention is directed to fused heterocyclic indane carboxamide derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.