170848-34-7Relevant articles and documents
Readily available amino acid building blocks for the synthesis of phosphole-containing peptides
van Zutphen, Steven,Margarit, Vicente J.,Mora, Guilhem,Le Floch, Pascal
, p. 2857 - 2859 (2007)
Nucleophilic substitution of a phospholide anion onto protected 3-iodoalanine leads to the formation of an amino acid with an appended phosphole in excellent yield. Manipulation of the protecting groups, leads to building blocks suitable for the synthesis of phosphole-containing polypeptides.
Z-selective olefin metathesis on peptides: Investigation of side-chain influence, preorganization, and guidelines in substrate selection
Mangold, Shane L.,Oleary, Daniel J.,Grubbs, Robert H.
, p. 12469 - 12478 (2014)
Olefin metathesis has emerged as a promising strategy for modulating the stability and activity of biologically relevant compounds; however, the ability to control olefin geometry in the product remains a challenge. Recent advances in the design of cyclom
Synthesis of C3-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step
Kotha, Sambasivarao,Todeti, Saidulu
, p. 371 - 377 (2019)
We demonstrate a new synthetic strategy toward star-shaped C3-symmetric molecules containing α-amino acid (AAA) derivatives and dipeptides. In this regard, trimerization and Negishi cross-coupling reactions are used as the key steps starting fr
Nickel-Catalyzed Cross-Coupling of Amino-Acid-Derived Alkylzinc Reagents with Alkyl Bromides/Chlorides: Access to Diverse Unnatural Amino Acids
Gou, Fei-Hu,Ma, Ming-Jian,Wang, An-Jun,Zhao, Liang,Wang, Haoyang,Tong, Jie,Wang, Ze,Wang, Zhen,He, Chun-Yang
supporting information, p. 240 - 244 (2022/01/12)
Unnatural α-amino acids are important synthetic targets in the field of peptide science. Herein we report an efficient, versatile, and straightforward strategy for the synthesis of homophenylalanine derivatives via the nickel-catalyzed Csp3–Csp3 cross-coupling of (fluoro)benzyl bromides/chlorides with natural α-amino-acid-derived alkylzinc reagents. The current protocol features the advantages of a low-cost nickel catalyst system, synthetic convenience, and the tolerance of rich functionality and stereochemistry.
ELONGATION FACTOR 1-ALPHA INHIBITORS AND USES THEREOF
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Paragraph 0551-0554; 0598-0603, (2021/08/13)
Disclosed herein, inter alia, are compounds for inhibiting Elongation Factor 1-alpha and uses thereof.
Synthesis method and application of 1-aza -5-germanium-5-alkyl bicyclic [3.3.3] undecane compound.
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, (2020/05/11)
The invention provides a 1-aza-5-germanium hetero-5-alkyl bicyclic [3.3.3] hendecane compound having a structure shown in the formula I, and the types of the 1-aza-5-germanium hetero-5-alkyl bicyclic[3.3.3] hendecane compound are expanded. The provided compound can serve as a nucleophilic reagent, the air and humidity conditions of the nucleophilic reagent are stable, and the efficiency of the Ge-Stille coupling reaction of aryl halogen and the 1-aza-5-germanium hetero-5-alkyl bicyclic [3.3.3] hendecane compound is high.