1383736-67-1Relevant articles and documents
Access to the pactamycin core via an epoxide opening cascade
Haussener, Travis J.,Looper, Ryan E.
, p. 3632 - 3635 (2012/09/05)
A synthetic strategy to establish five contiguous stereocenters, in a stereocontrolled manner, on the core structure of pactamycin is described. This sequence exploits the use of a Lewis acid mediated epoxide opening cascade to set the relative configuration of the C4-C5 diol while reversing the configuration at C7. This sequence provides the oxygenated core of pactamycin in just 11 steps.