13838-45-4

Usage

Uses

Used in Medicinal Chemistry:
5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID is used as a building block for the development of pharmaceutical drugs. Its unique structure and properties make it suitable for various biological and chemical processes, making it a promising candidate for the creation of new drugs with potential therapeutic applications.
Used in Pharmaceutical Drug Development:
5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID is used as a key component in the synthesis of new pharmaceutical drugs. Its potential applications in medicinal chemistry make it a valuable resource for researchers and drug developers, who can leverage its unique properties to create innovative and effective treatments for various diseases and conditions.

Upstream product

• 13838-43-2 ethyl 2-(2-(4-methoxy-2-nitrophenyl)hydrazono)propanoate 
• 13838-44-3 ethyl 5-methoxy-7-nitro-1H-indole-2-carboxylate 
• 96-96-8 4-methoxy-2-nitroaniline 
• 1000341-42-3 5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester 
• 61690-45-7 4-methoxy-2-nitrophenylhydrazine 

Downstream Products

• 10553-10-3 5-methoxy-7-nitro-1H-indole 

Relevant academic research and scientific papers

THERAPY AND PHARMACEUTICAL COMPOSITION

A novel class of compounds called perenosins, and their use in the treatment and/or prevention of cancer or a neoplastic condition.

Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors

Inhibition of xanthine oxidase (XO) has obviously been a central concept for controlling hyperuricemia, which causes serious and painful inflammatory arthritis disease such as gout. We discovered a series of novel 2-(indol-2-yl)thiazole derivatives as XO inhibitors at the level of nanomolar activity. Structure-guided design using molecular modeling program (Accelrys Software program) provided an excellent basis for optimization of 2-(indol-2-yl)thiazole compounds. Structure-activity relationship indicated that hydrophobic alkoxy group (isopropoxy, cyclopentoxy) at 5-position and hydrogen binding acceptor (NO2, CN) at 7-position of indole ring appear as critical functional groups. Among the compounds, 2-(7-nitro-5-isopropoxy-indol-2-yl)-4-methylthiazole-5-carboxylic acid (9m) exhibits the most potent XO inhibitory activity (IC50value: 5.1 nM) and the excellent uric acid lowering activity in potassium oxonate induced hyperuricemic rat model.

Perenosins: A new class of anion transporter with anti-cancer activity

A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl-/NO3- antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.