1383986-95-5Relevant academic research and scientific papers
Asymmetric transfer hydrogenations of β-N-substituted enamino esters with ammonia borane
Zhao, Weiwei,Feng, Xiangqing,Yang, Jing,Du, Haifeng
, p. 1193 - 1196 (2019)
Optically active β-amino acids and their derivatives are very useful building blocks in synthetic and medicinal chemistry. The catalytic asymmetric reduction of β-enamino esters is one of the most efficient approaches for their synthesis. Ammonia borane w
Synthesis of chiral β-amino acid derivatives by asymmetric hydrosilylation with an imidazole derived organocatalyst
Jones, Simon,Li, Xianfu
, p. 5522 - 5532 (2012/09/21)
The organocatalysed asymmetric hydrosilylation of a number of N-aryl and alkyl β-substituted enamino esters proceeds in generally good yield and enantioselectivity. Crucial to obtaining high yield and selectivity was the addition of benzoic acid as an additive and under these conditions, both N-alkyl and N-aryl substituents were well tolerated. β-Aryl and alkyl substituents were evaluated and a model proposed to account for the experimental observations based upon enamine tautomerisation and conformational preferences of the reactive ketimine intermediate.
