1384192-05-5Relevant academic research and scientific papers
Copper-catalyzed enantioselective 1,4-conjugate addition of dialkylzinc reagents to α,β- and α,β,γ,δ-unsaturated ketones
Rexiti, Rukeya,Lu, Jian,Sha, Feng,Wu, Xin-Yan
, p. 3596 - 3604 (2019/06/04)
An enantioselective Cu(II)-catalyzed conjugate addition of dialkylzinc reagents to α,β- or α,β,γ,δ-unsaturated ketones with chiral cyclohexane-based amidophosphine ligands was developed. With 2 mol% of Cu(OAc)2·H2O/L5, the conjugate
Paracyclophane-derived monodentate phosphoramidite ligands for copper-catalyzed asymmetric conjugate addition of diethylzinc to substituted chalcones
Han, Lei,Lei, Yang,Xing, Ping,Zhao, Xiao-Long,Jiang, Biao
, p. 3752 - 3757 (2015/05/05)
Copper-catalyzed asymmetric conjugate addition of diethylzinc to chalcones could be realized by using [2.2]paracyclophane-derived monodentate phosphoramidite ligands. The excellent yield and enantioselectivity (up to 98% yield and 95% enantiomeric excess) could be realized with low catalyst loading of 1.0 mol % and low ligand loading of 1.2%.
Switchable stereoselectivity: The effects of substituents on the D 2-symmetric biphenyl backbone of phosphoramidites in copper-catalyzed asymmetric conjugate addition reactions with triethylaluminium
Yu, Han,Xie, Fang,Ma, Zhenni,Liu, Yangang,Zhang, Wanbin
supporting information; experimental part, p. 1941 - 1947 (2012/09/25)
A highly enantioselective copper-catalyzed conjugate addition with triethylaluminium was developed using phosphoramidite ligands bearing a D 2-symmetric biphenyl backbone. For these ligands we demonstrated that the 3,3',5,5'-substituents on the biphenyl backbone can completely reverse the absolute configuration of the products. Copyright
The effects of solvent on switchable stereoselectivity: Copper-catalyzed asymmetric conjugate additions using D2-symmetric biphenyl phosphoramidite ligands
Yu, Han,Xie, Fang,Ma, Zhenni,Liu, Yangang,Zhang, Wanbin
, p. 5137 - 5142 (2012/08/07)
A highly enantioselective copper-catalyzed conjugate addition of diethylzinc to acyclic aromatic enones was developed with phosphoramidite ligands bearing a D2-symmetric biphenyl backbone. This type of reaction demonstrated that toluene and THF solvents can completely reverse the absolute configuration of the products, thus simplifying the process of accessing either enantiomer (S: 92% ee, 94% yield; R: 99% ee, 96% yield).
