138423-98-0

Usage

Uses

Used in Chemical Synthesis:
N-Acetic acid-indole-3-carboxaldehyde is used as a key intermediate in the synthesis of various indole-based compounds, which have applications in pharmaceuticals, agrochemicals, and other chemical industries. Its unique chemical structure allows for the formation of a resin, which can be employed in the immobilization of amines and their derivatives through reductive amination.
Used in Analytical Chemistry:
In the field of analytical chemistry, N-Acetic acid-indole-3-carboxaldehyde can be used as a derivatizing agent for the detection and analysis of various compounds, particularly amines. The formation of the indolecarboxaldehyde resin allows for the selective and efficient immobilization of target molecules, enabling their detection and quantification.
Used in Material Science:
N-Acetic acid-indole-3-carboxaldehyde can be utilized in the development of novel materials, such as resins and polymers, due to its ability to form a resin through coupling with an amino-resin. These materials can find applications in various industries, including coatings, adhesives, and composites, where their unique properties can be exploited for specific uses.
Used in Research and Development:
As a versatile organic compound, N-Acetic acid-indole-3-carboxaldehyde can be employed in research and development for the exploration of new chemical reactions, synthesis methods, and potential applications. Its solid-state nature and ability to form a resin make it an attractive candidate for studying various aspects of chemical reactivity and material properties.

InChI:InChI=1/C11H9NO3/c13-7-8-5-12(6-11(14)15)10-4-2-1-3-9(8)10/h1-5,7H,6H2,(H,14,15)

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 
• 7748-25-6 potassium chloroacetate 
• 27065-94-7 (3-formylindol-1-yl)acetic acid ethyl ester 
• 363590-49-2 2-(3-formyl-1H-indol-1-yl)acetic acid tert-butyl ester 
• 120-72-9 indole 

Downstream Products

• 588-46-5 N-(phenylmethyl)acetamide 
• 335207-46-0 1-[2-(4-morpholinyl)-2-oxoethyl]-1H-indole-3-carboxaldehyde 
• 138423-99-1 3-hydroxymethyl-N-carboxymethylindole 

Relevant academic research and scientific papers

COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula (I), or a pharmaceutically acceptable salt or composition thereof The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduce the excessive activation of complement.

New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: Discovery, characterization, and crystal structure in complex with the target

Terminal deoxynucletidyl transferase (TdT) is overexpressed in some cancer types, where it might compete with pol μ during the mutagenic repair of double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathway. Here we report the discove

PHARMACEUTICAL PREPARATIONS COMPRISING INSULIN, ZINC IONS AND A ZINC-BINDING LIGAND

Novel preparations comprising branched ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer. The preparations have a prolonged action designed for flexible injection regimes.

PHAMACEUTICAL PREPARATIONS COMPRISING INSULIN

Novel preparations comprising ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer wherein the ligand is extended by protamine that are capable of prolonging the ac-tion of insulin preparations.

Stabilised insulin compositions

The present invention provides pharmaceutical compositions comprising insulin and novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer. The resulting preparations have improved physical and chemical stability.

Solid-phase composite carrier and method

Functionalized supports and methods for solid phase synthesis. Preferably, the functionalized support is azlactone-functionalized.

PHARMACEUTICAL PREPARATIONS COMPRISING ACID-STABILISED INSULIN

Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.

Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer

Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.

Case studies in process screening and optimization utilizing a new automated reactor - Analysis system

The application of a new automated workstation for conducting solution-phase reactions in parallel during chemical process development is described. The fully automated reactor - analysis system is capable of reagent/reactant addition, temperature and agitation control, and sample extraction/quench/injection for online HPLC analysis. Both precision and accuracy of the fluidic delivery and sampling systems were measured through the use of standard ultraviolet chromophore solutions in conjunction with HPLC analysis. Agitation efficiency was evaluated using a phase-transfer catalysis reaction known to be rate-dependent on stirring frequency. Chemistry cases examined included several single and multistep reactions studied to identify the best reagent/solvent combinations (screening) and optimal levels of continuous variables such as temperature, concentration, and stoichiometry (optimization). A multistep route to a chiral substituted imidazolidin-2-one was developed from initial route scouting through reaction condition screening, optimization, and scale-up. Reactions performed included alkylation, reduction, oxidation, reductive amination, displacement, and cyclization.