1384272-98-3Relevant academic research and scientific papers
Primary alcohols from terminal olefins: Formal anti-Markovnikov hydration via triple relay catalysis
Dong, Guangbin,Teo, Peili,Wickens, Zachary K.,Grubbs, Robert H.
, p. 1609 - 1612 (2011)
Alcohol synthesis is critical to the chemical and pharmaceutical industries. The addition of water across olefins to form primary alcohols (anti-Markovnikov olefin hydration) would be a broadly useful reaction but has largely proven elusive; an indirect hydroboration/oxidation sequence requiring stoichiometric borane and oxidant is currently the most practical methodology. Here, we report a more direct approach with the use of a triple relay catalysis system that couples palladium-catalyzed oxidation, acid-catalyzed hydrolysis, and ruthenium-catalyzed reduction cycles. Aryl-substituted terminal olefins are converted to primary alcohols by net reaction with water in good yield and excellent regioselectivity.
