1384274-27-4

Basic information

• Product Name: (E)-N-(4-(N-(3-(benzyloxy)pyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide
• CAS NO: 1384274-27-4
• Molecular Weight: 537.577
• Mol File: 1384274-27-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N-(4-(N-(3-(benzyloxy)pyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(4-(N-(3-(benzyloxy)pyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide(1384274-27-4)
• EPA Substance Registry System: (E)-N-(4-(N-(3-(benzyloxy)pyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide(1384274-27-4)

Safety Data

• Hazardous Substances Data: 1384274-27-4(Hazardous Substances Data)

Upstream product

• 110223-15-9 2-amino-3-(phenylmethoxy)pyrazine 
• 100-51-6 benzyl alcohol 
• 50868-70-7 (E)-3-(2-nitrothiophen-5-yl)propenoic acid 
• 55785-89-2 (E)-3-(5-nitrothiophen-2-yl)acryloyl chloride 

Relevant articles and documents

Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein

Through high-throughput screening of 200000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small molecule inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chemical genetic approach, we utilized an NSA based chemical probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.