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110223-15-9

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110223-15-9 Usage

General Description

2-AMINOL-3-BENZYLOXYPYRAZINE is an organic compound with the molecular formula C12H13N3O and a molecular weight of 215.25 g/mol. It is a pyrazine derivative with a benzyl group and an amino group attached to the pyrazine ring. 2-AMINOL-3-BENZYLOXYPYRAZINE has potential applications in the field of pharmaceuticals and flavors due to its aromatic and heterocyclic structure. Its synthesis and characterization are of interest to researchers working in the field of organic chemistry and drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 110223-15-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,2,2 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 110223-15:
(8*1)+(7*1)+(6*0)+(5*2)+(4*2)+(3*3)+(2*1)+(1*5)=49
49 % 10 = 9
So 110223-15-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H11N3O/c12-10-11(14-7-6-13-10)15-8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,12,13)

110223-15-9 Well-known Company Product Price

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  • Alfa Aesar

  • (H63162)  2-Amino-3-benzyloxypyrazine, 97%   

  • 110223-15-9

  • 250mg

  • 515.0CNY

  • Detail
  • Alfa Aesar

  • (H63162)  2-Amino-3-benzyloxypyrazine, 97%   

  • 110223-15-9

  • 1g

  • 1646.0CNY

  • Detail
  • Alfa Aesar

  • (H63162)  2-Amino-3-benzyloxypyrazine, 97%   

  • 110223-15-9

  • 5g

  • 6860.0CNY

  • Detail

110223-15-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-3-benzyloxypyrazine

1.2 Other means of identification

Product number -
Other names 3-phenylmethoxypyrazin-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:110223-15-9 SDS

110223-15-9Relevant articles and documents

Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease

Elkamhawy, Ahmed,Park, Jung-eun,Hassan, Ahmed H.E.,Pae, Ae Nim,Lee, Jiyoun,Paik, Sora,Park, Beoung-Geon,Roh, Eun Joo

, p. 268 - 278 (2018)

Herein, we report synthesis and evaluation of new twenty-eight pyrazinyl ureas against β amyloid (Aβ)-induced opening of mitochondrial permeability transition pore (mPTP) using JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The neuroprotective effect of seventeen compounds against Aβ-induced mPTP opening was superior to that of the standard Cyclosporin A (CsA). Among them, 1-(3-(benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea (5) effectively maintained mitochondrial function and cell viabilities on ATP assay and MTT assay. Also, hERG channel assay presented safe cardiotoxicity profile for compound 5. In addition, using CDocker algorithm, a molecular docking model presented a plausible explanation for the elicited differences in efficiencies of the synthesized compounds to reduce the green to red fluorescence as indication of mPTP closure. Hence, this report presents compound 5 as the most promising pyrazinyl urea-based mPTP blocker up to date.

Urea analogs as neuroprotective agents

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Paragraph 0797; 0798, (2016/10/07)

In the brain the present invention refers to mPTP mitochondrial the selectively inhibit action of the improvement of the function of acting as an a neuro-protective agent central nervous system a using the zero therapeutic or prophylactic treatment of a disorder urea derivatives or a pharmaceutically acceptable salt, manufacturing method of these compounds, and methods of using these compounds is pharmaceutical composition contain as the active ingredient an relates.

IMIDAZO COMPOUNDS AND USES THEREOF

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Page/Page column 43-44, (2008/06/13)

N-substituted imidazopyrazinone compounds such as N-alkylated/aralkylated 7H-imidazo[1,2-a]pyrazin-8-one compounds and related analogs are disclosed. Pharmaceutical compositions and kits containing the N-substituted imidazopyrazinone compounds, as well as therapeutic uses thereof, including treatment of arrhythmia, are also disclosed.

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