138436-32-5

Upstream product

• 138436-27-8 (R)-(E)-2-<<<(-p-Methoxybenzyl)oxy>methoxy>methyl>-1-<(triisopropylsilyl)oxy>-5-methylhex-3-ene 
• 138436-21-2 (R)-(E)-5-Methyl-2-<<(triisopropylsilyl)oxy>methyl>hex-3-en-1-ol 
• 138436-22-3 (R)-(E)-1-Acetoxy-5-methyl-2-<<(triisopropylsilyl)oxy>methyl>hex-3-en 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 138436-27-8 Triisopropyl-[(E)-(S)-2-(4-methoxy-benzyloxymethoxymethyl)-5-methyl-hex-3-enyloxy]-silane 
• 138436-19-8 (R)-(E)-2-<<<(p-Methoxybenzyl)oxy>methoxy>methyl>-5-methylhex-3-en-1-ol 
• 88023-78-3 para-methoxybenzyl chloride 
• 13154-24-0 triisopropylsilyl chloride 

Downstream Products

• 152669-40-4 (S)-3-(4-methoxybenzyloxymethoxy)-2-(triisopropylsilyloxymethyl)-1-propanol 
• 155125-05-6 (S)-5-(4-methoxybenzyloxymethoxy)-4-(triisopropylsilyloxymethyl)-2(Z)-pentene 
• 155003-30-8 (S)-2-(4-Methoxy-benzyloxymethoxymethyl)-1-triisopropylsilanyloxy-hex-5-en-3-one 
• 155125-19-2 (2S,3R)-2-[(R)-1-Benzyloxymethoxymethyl-2-(4-methoxy-benzyloxymethoxy)-ethyl]-3-propyl-oxirane 
• 138760-95-9 (R)-2-(4-methoxybenzyloxymethoxy)-3(Z)-hepten-1-ol 
• 155125-14-7 (R)-2-(4-methoxybenzyloxymethoxy)-3(Z)-hepten-1-ol 
• 152669-30-2 (2S,3S,4R)-2-(4-Methoxy-benzyloxymethoxymethyl)-4-methyl-1-triisopropylsilanyloxy-hex-5-en-3-ol 
• 155125-04-5 (S)-1-(4-methoxybenzyloxymethoxy)-2-(triisopropylsilyloxymethyl)-3(Z)-heptene 
• 159992-97-9 (2R,3S)-2-[(S)-1-Benzyloxymethoxymethyl-2-(4-methoxy-benzyloxymethoxy)-ethyl]-3-propyl-oxirane 
• 138761-04-3 (Z)-(S)-2-(4-Methoxy-benzyloxymethoxymethyl)-hept-3-en-1-ol 

Relevant academic research and scientific papers

Asymmetric synthesis of protected α-alkyl-β-amino-δ-hydroxy esters by stereocontrolled elaboration of THYM*

Highly diastereoselective internal Michael addition of the carbamate moiety of enoate 1b [derived from asymmetrized tris(hydroxymethyl)methane (THYM*)] leads to oxazinone 4, which can, in turn, be alkylated with moderate to good diastereoselectivity in th

Stereodivergent synthesis of cis epoxides derived from asymmetrized 2-alkenyl-1,3-propanediols

Cis epoxides of any desired absolute stereochemistry have been obtained in a high enantio- and diastereodivergent manner via diastereospecific epoxidation of asymmetrized (Z)-2-alkenyl-1,3-propanediols, in turn obtained through a chemoenzymatic route, and a protection-deprotection 'trick' on hydroxy groups.

Chemoenzymatic Preparation of Asymmetrized Tris(hydroxymethyl)methane (THYM*) and of Asymmetrized Bis(hydroxymethyl)acetaldehyde (BHYMA*) as New Highly Versatile Chiral Building Blocks

A series of asymmetrized tris(hydroxymethyl)methanes 2 and bis(hydroxymethyl)acetaldehydes 3 have been prepared in both enantiomeric forms through a chemoenzymatic methodology.The key step is the highly enantioselective PPL-catalyzed monohydrolysis of 2(E)-alkenyl-1,3-diacetoxypropanes 25-27.A careful study on the effect of unsaturations adjacent to the prochiral center in a series of 2-substituted 1,3-diacetoxypropanes has confirmed the suggested beneficial effect of a ? system in that position but has also unveiled an unprecedented dramatic effect of double-bond configuration on enantioselectivity.A new empirical model for the interpretation of these and other results, based both on polarity and steric arguments, is proposed.This study provides a general protocol for the efficient synthesis of asymmetrized 1,3-propanediols bearing in position 2 saturated or unsaturated carbon chains.

Protecting group controlled diastereoselective allylation of asymmetrized bis (hydroxymethyl) acetaldehydes (BHYMA)

MgBr2 catalysed allylation of a series of diprotected asymmetrized bis (Hydroxymethyl) acetaldehydes 2 with allyltributylstannane proceeds with good diastereoselectivity. The stereochemical results are in line with a cyclic chelated transition state, where only one of the two CH2OR appendages, due to the different nature of protecting groups, is capable of coordinating the Lewis acid.