1384439-75-1Relevant academic research and scientific papers
Experimental and computational studies on the tautomerism of N-substituted 3-amino-5-oxo-4-phenyl-1H-pyrazolo-1-carboxamides with antibacterial activity
Kaczor, Agnieszka A.,Wróbel, Tomasz,Karczmarzyk, Zbigniew,Wysocki, Waldemar,Mendyk, Ewaryst,Poso, Antti,Matosiuk, Dariusz,Pitucha, Monika
, p. 188 - 196 (2013)
The tautomerism of N-substituted 3-amino-5-oxo-4-phenyl-1H-pyrazolo-1- carboxamides with antibacterial activity is studied with X-ray crystallography, IR, 1H and 13C NMR (including NOESY spectra) and quantum chemical calculations. It
Antioxidant evaluation of some semicarbazide, 1,2,4-triazolone and pyrazolone derivatives
Pitucha, Monika,Nowak, Renata
experimental part, p. 1004 - 1008 (2012/07/03)
1,2,4-Triazoles, pyrazoles and semicarbazides possessing heterocyclic ring 1-14 were synthesized as compounds with interesting pharmacological profiles. All were investigated in vitro for their antioxidant activity. Some compounds showed significant effect in the above assay. The most promising was a group of pyrazolone. The effect was dependent mainly on the substituent on the amide group. It was found that compounds 8 and 10 showed the highest antioxidant capacity comparable with the widely used reference, antioxidant 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid (Trolox).
