1384458-02-9Relevant academic research and scientific papers
Customizable units in Di- and tripeptides: Selective conversion into substituted dehydroamino acids
Saavedra, Carlos J.,Boto, Alicia,Hernandez, Rosendo
, p. 3788 - 3791 (2012/09/08)
The selective conversion of serine or threonine units of di- and tripeptides into substituted dehydroamino acids is reported. Thus, these common α-amino acids undergo a scission-phosphorylation process to give α-amino phosphonate residues. A Horner-Wadsworth-Emmons reaction with aldehydes or ketones follows to afford the final products with excellent Z-stereoselectivity (Z:E > 98:2). In this way, a single peptide precursor can selectively be transformed into a variety of derivatives.
