138450-22-3

Upstream product

• 37763-43-2 1-bromo-2-(bromomethyl)naphthalene 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 1178577-17-7 7-benzenesulfonyl-10-phenyl-9,10-dihydro-8H-10,10a-diazacyclopenta[b]phenanthren-11-one 
• 1178577-19-9 7-benzenesulfonyl-8-methyl-10-phenyl-9,10-dihydro-8H-10,10a-diazacyclopenta[b]phenanthren-11-one 
• 138450-27-8 C₄₂H₃₁Br₃O₄S₂ 

Relevant academic research and scientific papers

Synthesis of ring-fused oxazolo- and pyrazoloisoquinolinones by a one-pot Pd-catalyzed carboxamidation and aldol-type condensation cascade process

(Chemical Equation Presented) A three-component cascade process is described for the synthesis of ring-fused oxazolo- and pyrazoloisoquinolinones by a one-pot carboxamidation/aldol-type condensation reaction. The cascade process involves Pd-catalyzed carboxamidation of an aryl halide/active methylene compound with oxazolidinone or pyrazolidinone, and subsequent intramolecular base-catalyzed cyclization/dehydration through an aldol-type condensation process, to give ring-fused oxazolo- and pyrazoloisoquinolinones. This methodology provides an easy one-step approach to these important classesof nitrogen-containing heterocycles and can tolerate a wide array of functional groups, including ester, nitrile, methoxy, and halide.