1384512-36-0Relevant academic research and scientific papers
A new and facile access to the 2-(indol-3-yl)-3-nitriloquinolines based on Friedl?nder annulations
Shiri, Morteza,Zolfigol, Mohammad Ali,Pirveysian, Mahtab,Ayazi-Nasrabadi, Roya,Kruger, Hendrik G.,Naicker, Tricia,Mohammadpoor-Baltork, Iraj
, p. 6059 - 6064 (2012)
Preparation of 2-(indol-3-yl)-3-nitriloquinolines via Friedl?nder quinoline synthesis using 3-cyanoacetylindoles possessing an α-methylene group and ortho-amino arylketones have been described. This reaction took place in PEG-400 as a green solvent and it is catalyzed with polyphosphoric acid (PPA) to give novel types of quinolines containing both indoles and cyano functions in one step under thermal and microwave conditions.
