1384513-09-0Relevant articles and documents
Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity
Zhou, Haibin,Aguilar, Angelo,Chen, Jianfang,Bai, Longchuan,Liu, Liu,Meagher, Jennifer L.,Yang, Chao-Yie,McEachern, Donna,Cong, Xin,Stuckey, Jeanne A.,Wang, Shaomeng
, p. 6149 - 6161 (2012/08/28)
Bcl-2 and Bcl-xL are key apoptosis regulators and attractive cancer therapeutic targets. We have designed and optimized a class of small-molecule inhibitors of Bcl-2 and Bcl-xL containing a 4,5-diphenyl-1H-pyrrole-3-carboxylic acid core structure. A 1.4 ?