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ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1384513-05-6

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1384513-05-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1384513-05-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,4,5,1 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1384513-05:
(9*1)+(8*3)+(7*8)+(6*4)+(5*5)+(4*1)+(3*3)+(2*0)+(1*5)=156
156 % 10 = 6
So 1384513-05-6 is a valid CAS Registry Number.

1384513-05-6Downstream Products

1384513-05-6Relevant articles and documents

A potent and highly efficacious Bcl-2/Bcl-xL inhibitor

Aguilar, Angelo,Zhou, Haibin,Chen, Jianfang,Liu, Liu,Bai, Longchuan,McEachern, Donna,Yang, Chao-Yie,Meagher, Jennifer,Stuckey, Jeanne,Wang, Shaomeng

, p. 3048 - 3067 (2013/05/22)

Our previously reported Bcl-2/Bcl-xL inhibitor, 4, effectively inhibited tumor growth but failed to achieve complete regression in vivo. We have now performed extensive modifications on its pyrrole core structure, which has culminated in the discovery of 32 (BM-1074). Compound 32 binds to Bcl-2 and Bcl-xL proteins with Ki values of 50 values of 1-2 nM in four small-cell lung cancer cell lines sensitive to potent and specific Bcl-2/Bcl-xL inhibitors. Compound 32 is capable of achieving rapid, complete, and durable tumor regression in vivo at a well-tolerated dose schedule. Compound 32 is the most potent and efficacious Bcl-2/Bcl-xL inhibitor reported to date.

Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity

Zhou, Haibin,Aguilar, Angelo,Chen, Jianfang,Bai, Longchuan,Liu, Liu,Meagher, Jennifer L.,Yang, Chao-Yie,McEachern, Donna,Cong, Xin,Stuckey, Jeanne A.,Wang, Shaomeng

, p. 6149 - 6161 (2012/08/28)

Bcl-2 and Bcl-xL are key apoptosis regulators and attractive cancer therapeutic targets. We have designed and optimized a class of small-molecule inhibitors of Bcl-2 and Bcl-xL containing a 4,5-diphenyl-1H-pyrrole-3-carboxylic acid core structure. A 1.4 ?

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