1384517-91-2Relevant academic research and scientific papers
Synthesis and reactivity of pelletierine-derived building blocks and pelletierine analogs
Yan, Lok-Hang,Dagorn, Flore,Gravel, Edmond,Séon-Méniel, Blandine,Poupon, Erwan
experimental part, p. 6276 - 6283 (2012/08/28)
Lycopodium alkaloids are unique (and often impressive in terms of structures) polycyclic alkaloids that attract great interest from a biological point of view and that also provide ideal targets for total synthesis. Propylpiperidine units closely related to pelletierine are involved in the biosynthesis of these alkaloids. Therefore, stable pelletierine-like compounds, especially a (R)-phenylglycinol-based oxazolopiperidine analog, were prepared and their reactivity investigated. The compounds described in this work expand the tool-box of small building blocks in the piperidine series and pelletierine analogs and could be suitable for the synthesis of Lycopodium alkaloids following biosynthetically inspired strategies.
