1384521-66-7

Basic information

• Product Name: O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-2,4-dichlorobenzylcarbamothioate
• CAS NO: 1384521-66-7
• Molecular Weight: 408.308
• Mol File: 1384521-66-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-2,4-dichlorobenzylcarbamothioate(CAS DataBase Reference)
• NIST Chemistry Reference: O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-2,4-dichlorobenzylcarbamothioate(1384521-66-7)
• EPA Substance Registry System: O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-2,4-dichlorobenzylcarbamothioate(1384521-66-7)

Safety Data

• Hazardous Substances Data: 1384521-66-7(Hazardous Substances Data)

Upstream product

• 1378372-01-0 6-(hydroxymethyl)-2-methyl-1,4-dihydroquinazolin-4-one 
• 18967-41-4 2,4-dichloro-1-(isothiocyanatomethyl)benzene 
• 112888-43-4 4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline 

Relevant articles and documents

Synthesis and cytotoxic evaluation of quinazolin-4(3H)-one derivatives bearing thiocarbamate, thiourea or N-methyldithiocarbamate side Chains

We have previously found that the dithiocarbamate derivatives of quinazolin-4(3H)-one could act as cytotoxic agents against a panel of human tumor cell lines. To investigate the contribution of dithiocarbamate moiety to the cytotoxic activity, three series of novel quinazolin-4(3H)-one derivatives bearing thiocarbamate, thiourea or Nmethyldithiocarbamate side chains were synthesized and tested for their cytotoxic activity against human cancer cell lines A549, MCF-7, HeLa, HT29 and HCT-116 by MTT assay. The results showed that transformation of the dithiocarbamate moiety in lead compound I to thiocarbamate or thiourea led to a decrease or loss of cytotoxic activity. Some N-alkylated analogs of lead compound II preferentially inhibited the proliferation of A549 cells, although their potencies were not improved in comparison with the unalkylated counterparts. The structure-activity relationship obtained in this research will be beneficial for further synthesis and discovery of effective cytotoxic agents.