18967-41-4

Usage

Uses

Used in Agricultural Industry:
2,4-DICHLOROBENZYL ISOTHIOCYANATE is used as a biocidal and fungicidal agent for controlling pests and diseases in crops, contributing to increased agricultural productivity and crop protection.
Used in Pharmaceutical Industry:
2,4-DICHLOROBENZYL ISOTHIOCYANATE is used as a chemical intermediate in the synthesis of various pharmaceuticals, leveraging its strong antimicrobial properties to develop new drugs and treatments.
Used in Anticancer Applications:
2,4-DICHLOROBENZYL ISOTHIOCYANATE is used as a potential anticancer agent for inhibiting the growth of cancer cells in laboratory experiments, offering a promising avenue for the development of new cancer therapies.
Used in Pesticide Synthesis:
2,4-DICHLOROBENZYL ISOTHIOCYANATE is used as a chemical intermediate in the synthesis of various pesticides, providing a foundation for the development of effective pest control solutions.

InChI:InChI=1/C8H5Cl2NS/c9-7-2-1-6(4-11-5-12)8(10)3-7/h1-3H,4H2

Upstream product

• 95-00-1 2,4-dichloro-benzenemethanamine 
• 52626-40-1 (2,4-dichloro-benzyl)-dithiocarbamic acid; triethylamine salt 
• 108013-05-4 N-(2,4-dichloro-benzyl)-phthalimide 
• 20443-99-6 2,4-dichlorobenzyl bromide 
• 75-15-0 carbon disulfide 

Downstream Products

• 1384521-75-8 1-(2,4-dichlorobenzyl)-3-((2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)thiourea 
• 1384521-66-7 O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-2,4-dichlorobenzylcarbamothioate 
• 143543-74-2 2-(2,4-Dichlorobenzylamino)-2-thiazoline 
• 101080-62-0 (2,4-dichloro-benzyl)-thiourea 

Relevant academic research and scientific papers

Application of sulfur-containing isocyanate compounds in growth inhibition of blue-green algae

The invention relates to the application of sulfur-containing isocyanate compounds in the growth inhibition of blue-green algae. The compounds have structures as shown in a general formula I and a general formula II. In the general formula I, R1 represents a methyl group, a phenethyl group, a phenyl group, 4-methylpyridine or 3-methylpyridine. In the general formula II, M represents a carbonyl group, a methylene group and a methylene phenyl group; R3 represents hydrogen or chlorine; R4 represents oxygen, hydrogen, fluorine or chlorine; R5 represents oxygen, hydrogen, chlorine, a methyl group,fluorine, a benzene ring, bromine or a trifluoromethyl group; when R4 and R5 are oxygen, R4 and R5 are cyclized to form 1,3-dioxocyclopentene; R6 represents hydrogen, fluorine, bromine, a trifluoromethyl group, a methyl group and chlorine; and R7 represents hydrogen, a trifluoromethyl group, chlorine and bromine. The sulfur-containing isocyanate compounds with the structures as shown in the general formulas I and II provided by the invention have relatively good inhibition effect on blue-green algae, and can be used as an effective component of a blue-green algae algicide.

Synthesis and cytotoxic evaluation of quinazolin-4(3H)-one derivatives bearing thiocarbamate, thiourea or N-methyldithiocarbamate side Chains

We have previously found that the dithiocarbamate derivatives of quinazolin-4(3H)-one could act as cytotoxic agents against a panel of human tumor cell lines. To investigate the contribution of dithiocarbamate moiety to the cytotoxic activity, three series of novel quinazolin-4(3H)-one derivatives bearing thiocarbamate, thiourea or Nmethyldithiocarbamate side chains were synthesized and tested for their cytotoxic activity against human cancer cell lines A549, MCF-7, HeLa, HT29 and HCT-116 by MTT assay. The results showed that transformation of the dithiocarbamate moiety in lead compound I to thiocarbamate or thiourea led to a decrease or loss of cytotoxic activity. Some N-alkylated analogs of lead compound II preferentially inhibited the proliferation of A549 cells, although their potencies were not improved in comparison with the unalkylated counterparts. The structure-activity relationship obtained in this research will be beneficial for further synthesis and discovery of effective cytotoxic agents.

Synthesis and Octopaminergic Agonist Activity of 2-(Substituted benzylamino)-2-thiazolines

2-(Substituted benzylamino)-2-thiazolines (SBAT) were synthesized by a hydrochloric acid-catalyzed cyclization of the corresponding thioureas, using a reaction of 2-methylthio-2-thiazoline with substituted benzylamines or by alkylating 2-amino-2-thiazoline. 2-(Alkylthio)-2-thiazolines were obtained by alkylating 2-mercaptothiazoline.Most of the SBAT compounds activated adenylate cyclase in homogenates of cockroach ventral nerve cords; the effect of introducing substituents at the phenyl of the SBAT compounds on octopaminergic agonist activity was not significant. 2--2-thiazolines and 2-(alkylthio)-2-thiazolines were not significant octopaminergic agonists.Washing removed nearly all of the activity of one of the SBAT compounds, suggesting that the SBAT compounds bound reversibly to the octopaminergic receptor.